Drugs with important actions on smooth muscle

Question 1

Drug that causes contraction of the uterus

Answer 1

Oxytocin

Question 2

Distribution of histamine receptors H1, H2, and H3

Answer 2

Smooth muscle and mast cells; stomach, heart, and mast cells; nerve endings, CNS, respecitvely

Question 3

1st generation antihistamine that in highly sedating

Answer 3

Diphenhydramine

Question 4

2nd generation antihistamines

Answer 4

Fexofenadine, loratadine, and cetirizine

Question 5

H2 blocker that causes the most interactions with other drugs

Answer 5

Cimetidine

Question 6

5HT-1D/1B agonist used for migraine headaches

Answer 6

Sumatriptan, naratriptan, and rizatriptan

Question 7

Agents for reduction of postpartum bleeding

Answer 7

Oxytocin and ergonovine

Question 8

Agents used in treatment of carcinoid tumor

Answer 8

Cyproheptadine

Question 9

5HT-3 antagonist used in chemotheraputic induces emesis

Answer 9

Ondansetron, granisetron, dolasetron, and palonosetron

Question 10

Ergot alkaloid used as an illicit drug

Answer 10

LSD

Question 11

Dopamine agonist used in hyperprolactinemia

Answer 11

Bromocriptine

Question 12

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor in the development of angioedema

Answer 12

Bradykinin

Question 13

Drug causing depletion of substance P (vasodilator)

Answer 13

Caspaicin

Question 14

Prostaglandins that cause abortions

Answer 14

Prostaglandin E1 (misoprostol), PGE2, and PDGF2alpha

Question 15

Inhibitor of lipooxygenase

Answer 15

Zileuton

Question 16

Used in pediatrics to maintain patency of ductus arteriosis

Answer 16

PGE1 (Alprostadil)

Question 17

Prostaglandin used as 2nd line treatment of erectile dysfunction

Answer 17

PGE1 (Alprostadil)

Question 18

MoA and effect of nitric oxide

Answer 18

Stimulated cGMP which leads to vascular smooth muscle relaxation

Question 19

Muscarinic antagonist used in COPD

Answer 19

Ipratropium, tiotropium

Question 20

MoA of cromolyn

Answer 20

Blocks opening of Cl channels to prevent mast cell degranulation

Question 21

SE of long term (>5 days) corticosteroid therapy and remedy

Answer 21

Adrenal suppression, and weaning slowly, respectively