Drugs with important actions on smooth muscle Flashcards
Drug that causes contraction of the uterus
Oxytocin
Distribution of histamine receptors H1, H2, and H3
Smooth muscle and mast cells; stomach, heart, and mast cells; nerve endings, CNS, respecitvely
1st generation antihistamine that in highly sedating
Diphenhydramine
2nd generation antihistamines
Fexofenadine, loratadine, and cetirizine
H2 blocker that causes the most interactions with other drugs
Cimetidine
5HT-1D/1B agonist used for migraine headaches
Sumatriptan, naratriptan, and rizatriptan
Agents for reduction of postpartum bleeding
Oxytocin and ergonovine
Agents used in treatment of carcinoid tumor
Cyproheptadine
5HT-3 antagonist used in chemotheraputic induces emesis
Ondansetron, granisetron, dolasetron, and palonosetron
Ergot alkaloid used as an illicit drug
LSD
Dopamine agonist used in hyperprolactinemia
Bromocriptine
Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor in the development of angioedema
Bradykinin
Drug causing depletion of substance P (vasodilator)
Caspaicin
Prostaglandins that cause abortions
Prostaglandin E1 (misoprostol), PGE2, and PDGF2alpha
Inhibitor of lipooxygenase
Zileuton
Used in pediatrics to maintain patency of ductus arteriosis
PGE1 (Alprostadil)
Prostaglandin used as 2nd line treatment of erectile dysfunction
PGE1 (Alprostadil)
MoA and effect of nitric oxide
Stimulated cGMP which leads to vascular smooth muscle relaxation
Muscarinic antagonist used in COPD
Ipratropium, tiotropium
MoA of cromolyn
Blocks opening of Cl channels to prevent mast cell degranulation
SE of long term (>5 days) corticosteroid therapy and remedy
Adrenal suppression, and weaning slowly, respectively
