DRUGS TO Dyslipidaemia. Flashcards
Which density lipoprotein is receptor mediated.
LDL
HDL apoprotein accepts cholesterol from tissues. This can
then be absorbed ?
e absorbed by specific receptors in the liver
list the complications of atherosclerosis from the brain to toe
cerebral infarction
carotid atheroma
myocardial infarction
Aortic aneurysm
peripheral vascular disease intermittent claudication
gangrene
Types of lipid on white blood cells?
LDL
GDL
VLDL
TRIGLYCERIDES
CHOLESTEROL
Normal or desirable cholesterol levels
less than 5.2
value for LDL
< 2.59
Primary dyslipidemia
- 1⁰ forms are genetically determined
- Familial hypercholesterolaemia
secondary Dysli[idemia
2⁰ forms are consequences of other conditions / drugs * Type 2 diabetes mellitus
* Obesity * Alcoholism * Nephrotic syndrome
* Chronic renal failure
* Hypothyroidis
what is Dyslipidemia?
abnormal lipid level on the body, Fats in blood, including cholesterol and triglycerides.
Can you give an example of a primary dyslipidemia condition?
An example of a primary dyslipidemia condition is familial hypercholesterolemia, which is an inherited disorder leading to high levels of LDL cholesterol.
What are some medical conditions that can lead to secondary dyslipidemia
A: Medical conditions that can lead to secondary dyslipidemia include type 2 diabetes mellitus, obesity, nephrotic syndrome, chronic renal failure, and hypothyroidism.
In what way can obesity contribute to secondary dyslipidemia?
Obesity can contribute to secondary dyslipidemia by increasing the levels of LDL cholesterol and triglycerides, and lowering HDL cholesterol levels.
- Liver disease, &
Drugs = isotetrinoin & protease inhibitors (! HIV tx.
What are HMG CoA reductase inhibitors commonly known as?
HMG CoA reductase inhibitors are commonly known as statins
Can you name some examples of statins?
: Examples of statins include atorvastatin, simvastatin, and rosuvastatin
What is the function of bile acid sequestrants in treating dyslipidemia?
Bile acid sequestrants function by binding bile acids in the intestine, which reduces the reabsorption of cholesterol and lowers LDL cholesterol levels.
Can you provide an example of a bile acid sequestrant?
An example of a bile acid sequestrant is cholestyramine.
What are nicotinic acid and its derivatives used for in dyslipidemia treatment?
Nicotinic acid and its derivatives are used to lower triglyceride levels and increase HDL cholesterol levels.
Can you name two derivatives of nicotinic acid?
Two derivatives of nicotinic acid are acipimox and nicotinic acid itself
What class of drugs do bezafibrate, fenofibrate, and gemfibrozil belong to?
Bezafibrate, fenofibrate, and gemfibrozil belong to the class of drugs known as fibrates.
How do fibrates work in treating dyslipidemia?
Fibrates work by decreasing triglyceride levels and, to a lesser extent, increasing HDL cholesterol levels.
What is the role of inhibitors of cholesterol absorption in managing dyslipidemia
Inhibitors of cholesterol absorption reduce the amount of cholesterol absorbed by the intestine, thereby lowering blood cholesterol levels.
Can you give an example of a drug that inhibits cholesterol absorption?
An example of a drug that inhibits cholesterol absorption is ezetimibe.
What is a common supplement used to manage dyslipidemia that is categorized under ‘Other’?
A common supplement used to manage dyslipidemia that falls under the ‘Other’ category is omega-3 fatty acid.
