Drugs & Stroke

Question 1

Mechanism of Fibrinolytic Agents…

Answer 1

Plasmin degrades fibrin/trypsin to form protease, plasminogen deposits fibrin as clot forms and dissolves after repair.

Question 2

Examples of Fibrinolytic Agent…

Answer 2

Alteplase = plasminogen activators, given IV short acting within 3 hours of ischaemic event.

Question 3

Mechanism of Anti-Platelet Drugs…

Answer 3

Modify coagulation, success in venous thrombosis causing low pressure and slow flow.
Modify platelet aggregation and clot/thrombus breakdown.

Question 4

Examples of Anti-Platelet Drugs…

Answer 4

Aspirin - acute in first 24 hours before antiplatelet regime is established.
Dipyridamole / Clopidogrel.

Question 5

Mechanism of Anti-Coagulant Agents…

Answer 5

Diminishes concentration of clot factors.

Question 6

Examples of Anti-Coagulant Agents…

Answer 6

Heparin - IV immediate effect, activates anti-clot molecules.
Warfarin - inhibit vit K in liver to reduce assembling of clot factors so can’t form fibrin. Oral.

Question 7

Anti platelet Therapy…

Answer 7

Reduces incidence of further infarction.

Combined with 75mg Aspirin and 400mg Dipyridamole.