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Applied Pharmacology > CHD Drugs > Flashcards

CHD Drugs Flashcards

1
Q

How do Antihypertensives work on CHD?

A

Reduce BP/ heart filling / contraction strength / arterial resistance.

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2
Q

Mechanism of Nitrates / Nitrovasodilators…

A

Produce nitric oxide, increase cGMP in muscle cells to relax muscle and dilate vessels.

GTN - fast acting, short shelf life, metabolised by liver.

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3
Q

Side effects of Nitrates…

A

Headaches, Cerebral Vasodilation, Hypotension, Dizziness and Postural weakness

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4
Q

Mechanism of Statins (Lipid - cholesterol lowering drugs)…

A

HMG-CoA reductase inhibitor, rate limiting step in cholesterol synthesis, up regulates LDL cholesterol receptors.

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5
Q

Side Effects of Statins…

A

GI upset, abnormal liver tests and muscle problems e.g. myopathy.

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Applied Pharmacology (13 decks)

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