Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARM > Drugs part 2 > Flashcards

Drugs part 2 Flashcards

1
Q

Aldosterone Analog
Low Glucocorticoid effects
For primary adneral insufficiency

A

Fludrocortison (Mineralocorticoid replacement)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sensitizes Calcium sensing receptors (CaSR) in parathyroid glans to circulating calcium to lower PTH levels

A

CinaCALcet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Non-absorbable phosphate binder that prevents phosphate absorption from GI tract for Hyperphosphatemia in CKD.

A

Sevelamer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

↑ Catelcholamines (NE & Dopamine etc.) in the synaptic cleft. For ADHD.

A

Methylphenidate
Dextroamphetamine
Stimulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Block Dopamine D2 receptor (↑ cAMP)

High Potency → Neuro/motor symptoms
Low Potency → Anti-cholinergic, Anti- histamine, Anti- alpha 1 effects

A

Anti-psychotics
High → Haloperidol, Trifluoperazine, Fluphenazine
Low → Chlorpromazine, Thiridazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Not Well understood.
Most are 5HT & D2 antagonist
For schizophrenia or BP with psychotic symptoms

A 
Atypical Antipsychotics:
Apriprazole
–apines
–peridones
–rasidones
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Stimulates 5HT1a receptor
Does NOT cause ADDICTION, sedation, tolerance or Etoh interference.
For depression.

A

Buspirone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q 
Inhibits 5HT (seretonin) reuptake
For depression
A 
Fluvoxamine
Paroxetine
Sertraline
Escitalopram
Fluoxetine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Inhibit 5HT & NE reuptake

A

SNRIs:
Venlafaxine
Duloxetine
–nacipran

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

List the TriCyclic Anti-depressants which inhibit 5HT & NE reuptake

A

Amitriptyline
Nortriptyline
Imi(pramine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Non-Selective MAO inhibitors that cause ↑ levels of 5HT, NE, & Dopamine.

A

Phenelzine
Isocarboxid
Tranylcypromine
Selegiline

For when you’re in the MAO PITS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anesthetics with ↓ Blood solubility have _____

A

RAPID induction & recovery time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Anesthetics with ↑ LIPID solubility have ____

A

↑ Potency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Anesthetics with ↑ Blood solubility have _____

A

SLOWER induction & recovery time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Anesthetics with ↓ LIPID solubility have ____

A

↓ Potency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Nitrous Oxide (N2O) has ↓ Blood/Lipid solubility thus __ induction & __ Potency

A

Rapid

↓

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Equation used to determine the amount of inhaled anesthetic needed to knock out 50% of subjects.

A

Potency = 1/Min. Alveolar Conc.

Higher MAC = Lower potency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Halothane has ↑ Blood/Lipid solubility thus __ induction & __ Potency

A

Slow

↑

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

List the common suffixes for inhaled anesthetics

A

–fluranes
–halothanes
–Nitrous Oxide (N2O)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Inhaled anesthetics __ cerebral blood flow & __ cerebral metabolic demand

A

↑ flow

↓ metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Inhaled anesthetics or Succinylcholine can cause what fatal adverse effect?

A

Malignant Hyperthermia

*administer Dantrolene to cure

22
Q

IV anesthetic barbituate that facilitates GABAa.

Effects terminated by rapid redistribution into Fat

A

Thiopental

23
Q

IV anesthetic benzodiazepine that facilitates GABAa. Causes Anterograde amnesia

A

Midazolam

24
Q

IV anesthetic potentiates GABAa.
Used for short procedures
Rapid induction in ICU for sedation

A

Propofol

25
Q

Glutamate NMDA receptor ANTAGONIST
IV anesthetic
Causes Hallucinations, vivid dreams
Sympathomimetic

A

Ketamine

26
Q

Local anesthetics are administered with Epinephrine to enhance local action via vasoconstriction to ↓ bleeding/ blood flow (2)

A

↑ anesthesia concentration in the area

↓ systemic concentration

27
Q

Local Anesthetic ESTERS have the suffix

A

–caine

Only one letter i in the name
BenzocaIne

28
Q

Local Anesthetic AMIDES have the suffix

A

–caine

has 2 letter i in the name
LIdocaIne

29
Q

In infected (acidic) tissue anesthetics take on their CHARGED form & cannot penetrate the tissue as well. How is the dose adjusted?

A

Give higher dose of anesthetic

30
Q

Order of loss in sensation due to local anesthetics (4)

A

Pain → Temperature → Touch → Pressure

PTTP

31
Q

Block Leukotriene receptors

allergies

A

Montelukast

Zafirlukast

32
Q

5–Lipoxygenase inhibitor to ↓ leukotriene synthesis

A

Zileuton

33
Q

Anti IgE monoclonal
Antibody binds:
FcϵRI (IgE Fc receptor) &
unbound SERUM IgE

A

Omalizumab

34
Q

Inhibits Phosphodiesterase in smooth muscles to
↑ cAMP thus causing Bronchodilation
Used for COPD & Asthma

A

Theophylline

35
Q

Prevents Mast Cell Degranulation

A

Cromolyn

36
Q

Prevents eosinophil differentiation, maturation, & activation mediated by IL-5 via an Anti-IL-5 monoclonal antibody

A

Mepolizumab

Reslizumab

37
Q

Anti IL-5 RECEPTOR
(aka CD125)
monoclonal antibody

A

Benralizumab

38
Q

Reversible inhibitors of H1 histamine receptors

A

1st Generation
Diphenhydramine, Dimenhydrinate, Chlorphenramine, Doxylamine

2nd Generation
Loratadine, cetrizine, desloratadine, fexofenadine

39
Q

Thins respiratory secretions

Expectorant

A

Guaifensin

40
Q

Mucolytic

Liquifies mucus in COPD by disrupting disulfide bonds

A

N-acetylcystine

Acetaminophen OD antidote

41
Q

Antagonizes NMDA glutamate receptor

Antitussive

A

Dextromethorphan

can cause serotonin syndrome

42
Q

Endothelin receptor antagonist ↓ pulmonary vascular resistance

A

Bosetan

for pulmonary htn

43
Q

Inhibits PDE-5 to ↑ cGMP & prolong vasodilatory effects of NO

A

Sildenafil
(contraindicated with NO use)
used for erectile dysfunction

44
Q

PGI2 (prostacyclin) analog w/ vasodilatory effects on Pulmonary-vascular system

A

Epoprostenol

iloprost

45
Q

Beta 2 AGONIST for Asthma
Short acting
Long acting

A

Short: Albuterol
Long: Salmetrol, Formoterol

46
Q

Inhaled inhibitor of NFkB whose transcription factors induce production of TNF alpha

A

Fluticasone

Budesonide

47
Q

Competitively blocks M receptors to
↓ bronchoconstriction
for COPD > Asthma

A

Tiotropium

Ipratropium

48
Q

Binds Tubulin thus inhibiting fungal mitosis

A

Griseofulvin (for dermatophytes)

49
Q

Inhibits fungal Cell Wall synthesis

A

–Fungins (Echinocandins)

50
Q

Inhibits 14 alpha demethylase thus ↓ Egosterol synthesis from Lanosterol

A

–Azoles

PHARM (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions