CYP P450, Sulfas, antidotes Flashcards

1
Q

Sodium valproate

A

CYP–P450 Inhibitor

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2
Q

Isoniazid

A

CYP–P450 Inhibitor

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3
Q

Grape fruit juice

A

CYP–P450 Inhibitor

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4
Q

Ritonavir

A

CYP–P450 Inhibitor

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5
Q

Amiodarone

A

CYP–P450 Inhibitor

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6
Q

Metronidazole

A

CYP–P450 Inhibitor

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7
Q

Omeprazole

A

CYP–P450 Inhibitor

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8
Q

Ciprofloxacin

A

CYP–P450 Inhibitor

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9
Q

Sulfonamides

A

CYP–P450 Inhibitor

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10
Q

Ketoconazole

A

CYP–P450 Inhibitor

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11
Q

Fluconazole

A

CYP–P450 Inhibitor

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12
Q

Acute alcohol abuse

A

CYP–P450 Inhibitor

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13
Q

Chloramphenicol

A

CYP–P450 Inhibitor

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14
Q

Erythromycin/clarithromycin

A

CYP–P450 Inhibitor

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15
Q

Cimetidine

A

CYP–P450 Inhibitor

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16
Q

Chronic alcohol use

A

CYP–P450 Inducer

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17
Q

Modafinil

A

CYP–P450 Inducer

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18
Q

St. John’s wort

A

CYP–P450 Inducer

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19
Q

Phenytoin

A

CYP–P450 Inducer

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20
Q

Phenobarbital

A

CYP–P450 Inducer

21
Q

Nevirapine

A

CYP–P450 Inducer

22
Q

Rifampin

A

CYP–P450 Inducer

23
Q

Griseofulvin

A

CYP–P450 Inducer

24
Q

Carbamazepine

A

CYP–P450 Inducer

25
Q

Sulfonamide antibiotics

A

Sulfa Drug

26
Q

Sulfasalazine

A

Sulfa Drug

27
Q

Probenecid

A

Sulfa Drug

28
Q

Furosemide

A

Sulfa Drug

29
Q

Acetazolamide

A

Sulfa Drug

30
Q

Celecoxib

A

Sulfa Drug

31
Q

Thiazides

A

Sulfa Drug

32
Q

Sulfonyl ureas

A

Sulfa Drug

33
Q

Cyanide antidote

A

Hydroxocobalamin

Nitrites + Sodium Thiosulfate

34
Q

Heparin antidote

A

Protamine sulfate

35
Q

Lead antidote

A

Penicillamine
Dimercaprol
Succimer
Calcium disodium EDTA

36
Q

Digoxin (Digitalis) antidote

A

Digoxin specific antibody fragments

37
Q

Copper antidote

A

Penicillamine

Trientine

38
Q

Antimuscarinic/ Anticholinergic antidotes

A

Physostigmine (Crosses BBB)

Control hyperthermia

39
Q

AChE inhibitors, Organophosphate antidotes

A

Atropine > Pralidoxime

40
Q

Beta Blocker antidote

A

Atropine
Glucagon
Saline

41
Q

Carbon Monoxide antidote

A

100% O2

Hyperbaric O2

42
Q

Methanol, Ethylene Glycol (Anti-freeze) antidote

A

Fomepizole > ethanol + dialysis

43
Q

Methemoglobin antidote

A

Methylene Blue

Vitamin C

44
Q

Salicylate antidote

A

Sodium Bicarbonate (alkalinize urine), dialysis

45
Q

TCAs antidote

A

Sodium Bicarbonate (stabilizes cardiac cell membrane)

46
Q

Acetaminophen antidote

A

N-Acetylcysteine ( replenishes glutathione)

47
Q

Benzodiazepine antidote

A

Flumazenil

48
Q

Arsenic & Mercury antidote

A

Dimercaprol

Succimer

49
Q

Iron antidote

A

Deferoxamine
Deferiprone
Deferasirox