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Neuro IV > Drugs of Abuse > Flashcards

Drugs of Abuse Flashcards

1
Q

Mechanism of Action: Cocaine

A

Inhibit DAT (+SERT-NET) = blocks DA uptake

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2
Q

Mechanism of Action: Methamphetamine

A

Reverses DAT (+SERT-NET, VMAT) = releases DA

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3
Q

Mechanism of Action: Nicotine

A

Nicotinic receptor agonist = DA excitation

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4
Q

Mechanism of Action: MDMA (Ecstasy)

A

Reverses SERT > DAT, NET = 5HT releaser

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5
Q

Mechanism of Action: Opioids

A

meu receptor agonist (Gi/o) = disinhibition of DA neurons

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6
Q

Mechanism of Action: Alcohol

A

Facilitates GABA-A and inhibits NMDA receptors = excitation & disinhibition of DA neurons

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7
Q

Mechanism of Action: Benzodiazepines

A

Facilitates GABA-A = disinhibition of DA neurons

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8
Q

Mechanism of Action: Cannabinoids

A

CB1 receptor (Gi/o) agonist = disinhibition of DA neurons

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9
Q

Mechanism of Action: Hallucinogens (LSD, psilocybin)

A

5 HT2A (Gq) partial agonist

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10
Q

Mechanism of Action: Dissociative Anesthetics (Phencyclidine, Ketamine)

A

NMDA antagonist

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11
Q

Naloxone

A

Treatment of Opioid toxicity

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12
Q

Clonidine

A

Treatment of opioid withdrawal

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13
Q

Methadone

A

Treatment of opioid withdrawal

Long acting opioid agonist

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14
Q

Buprenorphine

A

Medication for opioid relapse, +/- naloxone

Mixed partial opioid agonist+naloxone

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15
Q

Disulfram

A

Medication for ethanol relapse

Inhibits acetalaldehyde dehydrogenase

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16
Q

Naltrexone

A

Opioid (w/buprenorphine) and ethanol relapse

Opioid antagonist

17
Q

Buproprion

A

Nicotine Addiction Med

Nicotinic Receptor Antagonist/DA reuptake inhibitor

18
Q

Varenicline

A

Nicotine Addiction Med

Partial a4B2 agonist

Neuro IV (6 decks)

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