Antipsychotics

Question 1

Chlorpromazine Mechanism

Answer 1

Typical: Blockade of D2 receptors > 5HT2A

Question 2

Haloperidol Mechanism

Answer 2

Typical: Blockade of D2 receptors > 5HT2A

Question 3

Aripiprazole

Answer 3

Atypical: Blockade of 5HT2A > D2 receptors

Question 4

Clozapine

Answer 4

Atypical: Blockade of 5HT2A > D2 receptors

Question 5

Olanzapine

Answer 5

Atypical: Blockade of 5HT2A > D2 receptors

Question 6

Quetiapine

Answer 6

Atypical: Blockade of 5HT2A > D2 receptors

Question 7

Risperidone

Answer 7

Atypical: Blockade of 5HT2A > D2 receptors

Question 8

Chlorpromazine Side Effects

Answer 8

ANS symptoms (dry mouth, tachycardia, constipation, orthostatic hypotension) Sedation

Question 9

Haloperidol Side Effects

Answer 9

Extrapyramidal Effects: Acute dystonia (treat w/antimuscarinics) Akathisia - reduce dose or add anticholinergics/BB/benzos Pseudoparkinsonism - treat w/anticholinergic or amantadine Tardive Dyskinesia - usually irreversible

Question 10

Clozapine Side Effects

Answer 10

Agranulocytosis, lowered seizure threshold

Question 11

Atypical Side Effects

Answer 11

Weight gain, altered thermoregulation, photosensitivity, lowered seizure threshold, neuroleptic malignant syndrome, QT prolongation