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Neuro IV > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

SSRIs Mechanism

A

Block SERT preventing serotonin reuptake

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2
Q

Fluoxetine

A

SSRI

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3
Q

Paroxetine

A

SSRI

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4
Q

Sertraline

A

SSRI

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5
Q

SNRI Mechanism

A

Block NET and SERT preventing reuptake of NE and 5HT

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6
Q

Venlafaxine

A

SNRI

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7
Q

TCADs Mechanism

A

Block NET and SERT preventing reuptake of NE and 5HT

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8
Q

Amitriptyline

A

TCAD

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9
Q

Notriptyline

A

TCAD

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10
Q

Desipramine

A

TCAD

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11
Q

Imipramine

A

TCAD

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12
Q

MAOIs

A

Inhibit monamine oxidase which degrade dopamine

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13
Q

Phenelzine

A

MAOI

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14
Q

Selegeline

A

MAOI

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15
Q

Buproprion

A

Norepinephrine and dopamine reuptake inhibitor

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16
Q

Trazadone

A

Mixed postsynaptic antagonist/serotonin reuptake inhibitor

17
Q

Mirtazapine

A

alpha2 adrenergic block = increased NE release

18
Q

St. Johns Wort

A

Several plant constituents act in combination of reuptake inhibitors and MAOI

19
Q

SSRI Side Effects

A

Acute: diarrhea, nausea, jitters, anxiety, dry mouth, P450 inhibition
Delayed: sexual side effects, weight gain, cognitive blunting
+MAOIs = serotonin syndrome (hyperthermia, rigidity, confusion, HTN)

20
Q

SNRI Side Effects

A

Better tolerated than TCADs

HTN, anxiety, greater withdrawal symptoms than SSRIs,

21
Q

TCAD Side Effects

A

Sedation, anticholinergic effects, weight gain, sex problems

Dangerous overdose - arrhythmias, sudden death, seizures

22
Q

MAOI Side Effects

A

Postural hypotension, HTN crisis from eating foods rich in tyramine (sausage, aged cheese, wine),
seizures, shock, hyperthermia in overdose

23
Q

Buproprion Side Effects

A

Higher seizure risk, anxiety

24
Q

Trazadone Side Effects

A

Drowsiness (used for insomnia)

25
Q

Mirtazapine Side Effects

A

Somnolence, weight gain

26
Q

St. Johns Wort Side Effects

A

P450 inducer

27
Q

Escitralopram

A

SSRI

28
Q

Citalopram

A

SSRI

29
Q

Duloxetine

A

SNRI

30
Q

Clomipramine

A

TCAD

Neuro IV (6 decks)

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