Drugs List block 2 Flashcards
Diamorphine
An analgesic (opiate receptor agonist ) Mu opoid agonist Attenuates pain Can be taken orally or injected Metabolized into morphine (faster with injection)
Oxygen
Healthy should be greater than 96% sat
Less than 88 is bad
Treatments include mask nasal cannula and tracheal intubation
B blockers
Reduction in heart rate bp and cardiac output
Competed with sympathomimetic neurotransmitters
All end in olol
Atenolol
Similar properties to propanolol but no negative inotropuc effect
Not commonly used most likely bioprolol
Propanolol
Helps with many heart disorders and migraines anxiety etc
Bendroflumethiazide
Thiazide diuretic
Vasodilation and urinary excretion of water
Inhibits nacl transporter blocking chloride reabsorption so more secreted out
Inhibits sodium transport across the renal tubular epithelium by binding to nacl transporter so increased potassium excretion
Antigypertensive
Activates KCa channel
Inhibits carbonic anhydrases in smooth muscle
Digoxin
Used to treat heart failure and atrial fibrillation
Inhibits knaatpase membrane pump so more calcium
More calcium promotes activation of contractile proteins eg myosin and actin
Helps electrical activity by shortening action potential increasing depolarization and decreasing max diastolic potential
Amiodarone
Antianginal and antirrhythmic k channel blocker class 3 antarrhythmic Prolonging myocardial cell action potential duration and refractory period Non competitive b adrenic receptor Also has calcium channel blocker like actuations on SA and av nodes Increases refractory period Slows intracardic conduction Defibs now more common
Warfarin
Anticoagulant and vitamin k antagonist
Prevents and treats
Thromboelic disease and prevents ischemic stroke
In pregnant patients with AF it can cross placental parried and lead to death
Inhibits vitamin k resurface reducing levels of reduced vitamin k
Competitive ace inhibitor drugs
End in pril Ramipril Enalapril Lisinopril Captopril
Ace inhibitor role
Concerts ATI to ATII
regulates blood pressure
Key component in RAAS
increases blood pressure by
Stimulating secretion of aldosterone from adrenal cortex
Stimulate vasopressin secretion from posterior pituitary gland
Causes vasoconstriction
Ace domains
C domain involved in blood pressure regulation and n domain involved in hematopoietic stem cell differentiation and proliferation
Ace inhibitors have a greater inhibitory effect on c domain
Norepinephrine
Is a vasoconstrictor Inotropic stimulator of heat and dilator of coronary arteries Secreted by adrenal medulla Precursor of epinephrine For infusion or cardiovascular support
Verapamil
L type Calcium channel blocker
Reduction of isotropy and chronotropy reducing heart rate and blood pressure
Two enantiomers r version more effective at reducing blood pressure and s 20 times more potent at prolonging the pr interval
Only be given via IV
