Drug List Block 3

Question 1

Chloropamazine

Answer 1

Antagonist on dopaminergic seretonergic histaminergic alpha muscarinic
Antiemetic and intractable hiccup
Pro version now used due to long term side effects

Question 2

Domperidone

Answer 2

Dopamine receptor d2 and d3

Gastrointestinal emptying adjunct and peristaltic stimulant

Question 3

Metoclopramide

Answer 3

Dopamine receptor agonist
Inhibits gastric smooth muscle relaxation so decreases reflux
Improved acid clearance by increasing amplitude of peristaltic contractions

Question 4

Perphanazine

Answer 4

10 to 15 times more potent than the chloro one
Inhibits dopamine receptors
And ones in chemoreceptor trigger zone and vomit centre
Has a greater behavioural potency

Question 5

Histamine antagonists

Answer 5

Cyclizine helps with nausea and vertigo anticholinergic effects and central nervous system depressant
Cinnarizine also inhibits d2 receptors ach receptors and vascular smooth muscle contraction by blocking L and T calcium channels
Promethazine anticholinergic and sedative effects

Question 6

Ach antagonist hyoscine

Answer 6

Scopolamine helps prevent motion sickness

Acts on communication between vestibular system and vomiting centre

Question 7

Ondanesteron

Answer 7

Seretonin 5HT receptor antagonist with a low affinity for dopamine receptors
Inhibits both centrally (CTZ) and peripherally (GI tract)
Granniesteron is how used

Question 8

Non steroidal anti inflammatories

Answer 8

Aspirin irreversible
Ibuprofen reversible
Naproxen
COX inhibitors

Question 9

Peptic ulcer treatment :proton pump inhibitors

Answer 9

Esomrprazole and omeprwzole (proton pump inhibitors)

Question 10

Ranitidine

Answer 10

Histamine antagonist

So reduces effects of subsances that promote acid secretion eg gastrin

Question 11

Magnesium Trisilicate

Answer 11

Neutralizes gastric acid ang acid

Binds bile acids