DRUGS- inhibitors of protein synthesis (fun facts!)

Question 1

30S Inhibitors

50S inhibitors

Answer 1

30S: aminoglycosides, tetracycline
50S: linezoilid, macrolides, chloramphenicol, clindamycin, quinupristin/dalfopristin

Question 2

interfere with mito ribosomes

Answer 2

linezolid, tetracycline and chloramphenicol (bone marrow suppression)

Question 3

drugs that can be used for MRSA

Answer 3

linezolid

Question 4

why do you cotreat for aminoglycosides

Answer 4

cotreat with something that can penetrate the cell wall (penicillin)
need combos for more energy!

Question 5

which aminoglycoside is less susceptible to enzyme inactivation

Answer 5

amikacin

==> broader spectrum (pseudomonas)

Question 6

drugs that should not be used in prego people

Answer 6

tetracyclines, aminoglycosides, clarithromycin

Question 7

Borrelia Burgdoferi phenotype

Answer 7

persister phenotype:

shift b/t different genetically homogenous forms to stop from being killed

Question 8

gray baby syndrome and drug involved

Answer 8

chloramphenicol
permis dont have enzyme glucuronyl transferase and decreased renal function ==> high levels of the drug accumulate ==> heart probs and resp collapse

Question 9

methylation of what drugs affects 23s rRNA binding site

Answer 9

macrolides, clindamycin, and quin/dalf

Question 10

inhibit cyt P450 enzyme

Answer 10

macrolides, quin/dalf