Drugs In Pregnancy Flashcards
Mat hyperthyroidism
90% secondary to Graves
Propylthiouracil> carbimazole
Lowest dose required to keep free thyroxine at upper limit of normal
(Reduce fetal hypothyroidism as a side effect)
Euthyroid for 4 weeks -> stop medication under close monitoring
Hyperemesis gravidarium
Oral antiemetics: promethazine Dehydration/significant ketonuria = admit IV fluids, NBM Metoclopromide, ondansetron Thiamine supplements
Obstetric cholestasis
Chlorphenamine- for pruritus
Oral vit K supplements
Ursodeoxycholic acid - reduce bile salt accumulation
PID
Doxycycline CI
Tetracyclines deposit in teeth and bones, delaying growth
If breastfeeding stains baby’s teeth
Alt = macrolide erythromycin, treatment of choice for PROM
Analgesia
1st line paracetamol
2nd line diclofenac
CI in pregnancy and when breast feeding: opiates e.g. Codeine
CI
Acitretin Methotrexate Me bendable Fluconazole Quinolones: ciprofloxacin Tetracyclines: doxycycline
Relative CI
Sodium valproate