Drugs in Inflammation Flashcards
What is chronic inflammation?
Abnormal, sustained inflammation
(Lecture 14, Slide 5)
Why does inflammation result in increased heat and redness?
Due to increased blood flow
(Lecture 14, Slide 8)
How does inflammation cause pain?
During inflammation, the immune system releases prostaglandins and histamine which can activate nerve endings and cause pain
(Lecture 14, Slide 10)
How does inflammation cause swelling?
Blood vessel leakage leads to swelling, and this is increased by histamine and prostaglandins, which are released by the immune system during inflammation.
(Lecture 14, Slide 11)
What do polymorphs do during inflammation?
They swallow bacteria via phagocytosis
(Lecture 14, Slide 14)
Why are polymorphs especially abundant in the lung?
As there is a higher risk of infection
(Lecture 14, Slide 14)
What do polymorphs contain?
Enzymes and free radical oxygen
(Lecture 14, Slide 14)
How does free radical oxygen destroy cells?
By combining with organic molecules
(Lecture 14, Slide 17)
What does excess free radicals result in?
Tissue damage and ulceration
(Lecture 14, Slide 17)
What appears after polymorphs in inflammation?
Macrophages
(Lecture 14, Slide 18)
How do the properties of macrophages compare to polymorphs?
Similar properties but macrophages are larger and synthesise complement
(Lecture 14, Slide 18)
What is TNF?
TNF stands for tumour necrosis factor and it is a cytokine secreted by T-lymphocytes
(Lecture 14, Slide 19)
What can excess TNF cause?
Tissue damage
(Lecture 14, Slide 19)
How do B-lymphocytes kill invaders?
By synthesising antibodies which stick to and kill invaders
(Lecture 14, Slide 19)
What is rheumatoid arthritis?
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that primarily affects the joints, causing pain, stiffness, swelling, and loss of function.
(Lecture 14, Slide 22)