Drugs in endocrine Flashcards
Examples of drugs that block hormone release
Somatostatin analogues
Diazoxide
GnRH modulators
Dopamine receptor agonist
Drugs that block hormone production
Antithyroid drugs - carbimazole, propothyauracil
Ketoconazole + metyrapone
What are ketoconazole + metyrapone used for
Block steroid synthesis
Cushings disease
Antithyroid drugs
Block tyrosine iodination
Carbimazole, propothyouracil
Drugs that block hormone action
Tamoxifen - SERM
Cinacalcet - PTH receptor blocker
Alpha + beta adrenoreceptor blockers - phaechromocytoma
Beta blockers - hyperthryoidism
Pegvisomant - GH receptor blocker
Medical treatment for phaeochromocytoma
alpha + beta adrenoreceptor blockers
Short term symtpom control in hyperthyroidism
Beta blockers
What treat excess prolactin with
Dopamine receptor agonists - shrink tumours and eventually can cure with prolonged use
Prolactin secreting tumours features
Men - hypogonadism
Women - secondary amenorrhea and infertility
How should replace steroids medically in addisons
Natural diurnal variation - high dose at 9am, lower dose at 4pm
What can reduce thryrozine absorption
Oral iron and antacids
What hormone is difficult to monitor treatment efficacy
Steroid replacement - ACTH and cortisol levels may not refelct - listen to paitent
