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First Aid Pharm > Drugs: GI > Flashcards

Drugs: GI Flashcards

1
Q

Ondansetron AE

A

Headache, constipation, prolong QT

5HT Antagonist

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2
Q

Bismuth use

A

ulcer healing, traveler’s diarr

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3
Q

Cimetidine AE

A

potent P450 inhib

anti-androgenic (gynecomastia, prolactin release, impotence, dec libido)

Cross BBB (confusion, HA) and placenta

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4
Q

Metoclopramide use

A

DM/ post op gastroparesis; antiemetic (D2-R in CNS chemoreceptor trigger zone)

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5
Q

Metoclopramide DDI

A

Dig and DM drugs

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6
Q

Sulfasalazine AE

A

malaise, nausea, sulfamide toxicity, reversible oligospermia

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7
Q

Nizatidine is a

A

H2 blocker

Take H2 blockers before you DINE. table for 2

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8
Q

Ondansetron use

A

post op and chemo emesis

keep on dancing with ondansetron

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9
Q

PPI AE

A

inc risk for C. diff and pneuma, dec Mg with long use

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10
Q

Misoprostol contra

A

pregnant (abortive)

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11
Q

Bismuth MOA

A

bind/ protect ulcer base

to allow HCO3 sec to reestablish pH gradient of mucus layers

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12
Q

Orlistat use

A

weight loss

lipase inhibitor

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13
Q

Metoclopramide contra

A

parkinsons, small bowel obstrux

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14
Q

Metoclopramide MOA

A

D2-R antagonist: inc resting tone, contractility, LES tone and motility

doesn’t effect colon transport time

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15
Q

Aluminum hydroxide AE

A

constipation, hypophosphatemia, weakness, osteodystrophy, seizure

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16
Q

antacids AE

A

hypoK, effect abs/exc and bioavail of drugs by altering pH and delaying gastric emptying

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17
Q

Calcium carbonate AE

A

hyperCa, rebound acid

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18
Q

cimetidine and ranitidine

A

decrease Cr exc

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19
Q

cimetidine is a

A

H2 blocker

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20
Q

dexlansoprazole is a

A

PPI

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21
Q

esomeprazole is a

A

PPI

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22
Q

famotidine is a

A

H2 blocker

23
Q

H2 blocker MOA

A

reversibly block H2R on parietal cells to dec H sec

24
Q

H2 blocker use

A

peptic ulcer, gastritis, mild GERD

25
Q

lactulose is a

A

osmotic laxative

26
Q

lactulose use

A

osmotic laxative, hepatic encepahalopathy

gut flora metab to lactic/acetic acid to propmote NH4+ exc (to reduce NH3 going to brain)

27
Q

lansoprazole is a

A

PPI

28
Q

lung abscess tx

A

clindaymcin (usually anaerobes)

29
Q

magnesium citrate is a

A

osmotic laxative

30
Q

Magnesium hydroxide is a

A

osmotic laxative and antacid

31
Q

Magnesium hydroxide AE

A

diarr, hyporeflexia, hypotension, cardiac arrest

32
Q

metoclopramide AE

A

parkinsonism, tardive dyskinesia, diarr

33
Q

misoprostol AE

A

diarr

34
Q

misoprostol MOA

A

PGE1 analog to inc gastric mucous barrier and dec acid production

35
Q

misoprostol use

A

prevent NSAID induced ulcer, maintain PDA

36
Q

octreotide AE

A

nausea, cramps, streatorrhea

37
Q

octreotide MOA

A

long acting somatostatin

splanchnic vasoX and inhibits many GI hormones

38
Q

octreotide use

A

acute variceal bleeding, acromegaly, VIPoma, carcinoid tumor

39
Q

omeprazole is a

A

PPI

40
Q

Ondansetron AE

A

HA, constipation, prolong QT

5HT antagonist

41
Q

orlistat AE

A

steatorrhea, dec abs of vit ADEK

42
Q

orlistat MOA

A

inhibit lipase to dec breakdown/ abs of dietary fat

43
Q

osmotic laxative use

A

constipation

44
Q

pantoprazole is a

A

PPI

45
Q

polyethylene glycol is a

A

osmotic laxative

46
Q

PPI MOA

A

irreversibly inhibit H/K ATPase in parietal cells

47
Q

PPI use

A

peptic ulcer, gastritis, GERD, Zollinger Ellison syndrome

48
Q

ranitidine is a

A

H2 blocker

49
Q

sucralfate MOA

A

bind/ protect ulcer base

to allow for HCO3 sec to reestablish pH gradient of mucus layers

50
Q

sucralfate use

A

ulcer healing, traveler’s diarr

51
Q

sulfasalazine MOA

A

silfapyridine (ABX) + 5 amino salicylic acid (anti-inflamm)

activated by colonic bacteria

52
Q

sulfasalazine use

A

UC and chrohns

53
Q

tx UC

A

steroid, azathioprine, TNFa inhib, ABX

First Aid Pharm (9 decks)

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