Drugs: GI

Question 1

Ondansetron AE

Answer 1

Headache, constipation, prolong QT

5HT Antagonist

Question 2

Bismuth use

Answer 2

ulcer healing, traveler’s diarr

Question 3

Cimetidine AE

Answer 3

potent P450 inhib

anti-androgenic (gynecomastia, prolactin release, impotence, dec libido)

Cross BBB (confusion, HA) and placenta

Question 4

Metoclopramide use

Answer 4

DM/ post op gastroparesis; antiemetic (D2-R in CNS chemoreceptor trigger zone)

Question 5

Metoclopramide DDI

Answer 5

Dig and DM drugs

Question 6

Sulfasalazine AE

Answer 6

malaise, nausea, sulfamide toxicity, reversible oligospermia

Question 7

Nizatidine is a

Answer 7

H2 blocker

Take H2 blockers before you DINE. table for 2

Question 8

Ondansetron use

Answer 8

post op and chemo emesis

keep on dancing with ondansetron

Question 9

PPI AE

Answer 9

inc risk for C. diff and pneuma, dec Mg with long use

Question 10

Misoprostol contra

Answer 10

pregnant (abortive)

Question 11

Bismuth MOA

Answer 11

bind/ protect ulcer base

to allow HCO3 sec to reestablish pH gradient of mucus layers

Question 12

Orlistat use

Answer 12

weight loss

lipase inhibitor

Question 13

Metoclopramide contra

Answer 13

parkinsons, small bowel obstrux

Question 14

Metoclopramide MOA

Answer 14

D2-R antagonist: inc resting tone, contractility, LES tone and motility

doesn’t effect colon transport time

Question 15

Aluminum hydroxide AE

Answer 15

constipation, hypophosphatemia, weakness, osteodystrophy, seizure

Question 16

antacids AE

Answer 16

hypoK, effect abs/exc and bioavail of drugs by altering pH and delaying gastric emptying

Question 17

Calcium carbonate AE

Answer 17

hyperCa, rebound acid

Question 18

cimetidine and ranitidine

Answer 18

decrease Cr exc

Question 19

cimetidine is a

Answer 19

H2 blocker

Question 20

dexlansoprazole is a

Answer 20

PPI

Question 21

esomeprazole is a

Answer 21

PPI

Question 22

famotidine is a

Answer 22

H2 blocker

Question 23

H2 blocker MOA

Answer 23

reversibly block H2R on parietal cells to dec H sec

Question 24

H2 blocker use

Answer 24

peptic ulcer, gastritis, mild GERD

Question 25

lactulose is a

Answer 25

osmotic laxative

Question 26

lactulose use

Answer 26

osmotic laxative, hepatic encepahalopathy gut flora metab to lactic/acetic acid to propmote NH4+ exc (to reduce NH3 going to brain)

Question 27

lansoprazole is a

Answer 27

PPI

Question 28

lung abscess tx

Answer 28

clindaymcin (usually anaerobes)

Question 29

magnesium citrate is a

Answer 29

osmotic laxative

Question 30

Magnesium hydroxide is a

Answer 30

osmotic laxative and antacid

Question 31

Magnesium hydroxide AE

Answer 31

diarr, hyporeflexia, hypotension, cardiac arrest

Question 32

metoclopramide AE

Answer 32

parkinsonism, tardive dyskinesia, diarr

Question 33

misoprostol AE

Answer 33

diarr

Question 34

misoprostol MOA

Answer 34

PGE1 analog to inc gastric mucous barrier and dec acid production

Question 35

misoprostol use

Answer 35

prevent NSAID induced ulcer, maintain PDA

Question 36

octreotide AE

Answer 36

nausea, cramps, streatorrhea

Question 37

octreotide MOA

Answer 37

long acting somatostatin splanchnic vasoX and inhibits many GI hormones

Question 38

octreotide use

Answer 38

acute variceal bleeding, acromegaly, VIPoma, carcinoid tumor

Question 39

omeprazole is a

Answer 39

PPI

Question 40

Ondansetron AE

Answer 40

HA, constipation, prolong QT 5HT antagonist

Question 41

orlistat AE

Answer 41

steatorrhea, dec abs of vit ADEK

Question 42

orlistat MOA

Answer 42

inhibit lipase to dec breakdown/ abs of dietary fat

Question 43

osmotic laxative use

Answer 43

constipation

Question 44

pantoprazole is a

Answer 44

PPI

Question 45

polyethylene glycol is a

Answer 45

osmotic laxative

Question 46

PPI MOA

Answer 46

irreversibly inhibit H/K ATPase in parietal cells

Question 47

PPI use

Answer 47

peptic ulcer, gastritis, GERD, Zollinger Ellison syndrome

Question 48

ranitidine is a

Answer 48

H2 blocker

Question 49

sucralfate MOA

Answer 49

bind/ protect ulcer base to allow for HCO3 sec to reestablish pH gradient of mucus layers

Question 50

sucralfate use

Answer 50

ulcer healing, traveler's diarr

Question 51

sulfasalazine MOA

Answer 51

silfapyridine (ABX) + 5 amino salicylic acid (anti-inflamm) activated by colonic bacteria

Question 52

sulfasalazine use

Answer 52

UC and chrohns

Question 53

tx UC

Answer 53

steroid, azathioprine, TNFa inhib, ABX