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First Aid Pharm > DIT Days 3-4 > Flashcards

DIT Days 3-4 Flashcards

1
Q

cholinergic excess/organophosphate poisoning

A

DUMBBELSS

diarr, urination, miosis, bronchospasm, brady, excit skel muscle/CNS, lacrimation, salivation, sweat

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2
Q

endogenous agonist of opioid rec?

A

mu: endorphin
delta: enkephalin
kappa: dynorphin

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3
Q

uvula deviates R

A

L nuc ambiguus damage

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4
Q

branchial pouch 1:

A

mastoid air cell, middle ear cavity, eustachian tubes

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5
Q

branchial pouch 2

A

lining of palatine tonsils

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6
Q

branchial pouch 3

A

thymus, inferior parathyroid

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7
Q

branchial pouch 4

A

superior parathyroid glands

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8
Q

structures running through the cavernous sinus?

A

CN3, 4, 6, 5i, 5ii, internal carotid artery

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9
Q

alpha blocker with little effect on BP?

A

tamsulosin: selective alpha1 antag

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10
Q

non competitive inhibitor effect on Km and vmax

A

dec vmax, no change Km

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11
Q

competitive inhibitor effect on Km and vmax

A

no change on max and inc Km

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12
Q

CYP inhibitors

A

CRACK AMIGOS
cimetidine, ritonavir, amio, cipro, keotcona, acute alc use, macrolides, isoniazid, grapefruit juice, omeprazole, sulfonamides

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13
Q

what agents tx urge incontinence?

A

on the damn toilet

oxybutynin, tolterodine, darifenacin (and solifenacin), trolspium

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14
Q

dec km what happens to potency?

A

inc

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15
Q

change km what happened to efficacy?

A

no change

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16
Q

inc vmax what happens to efficacy?

A

inc

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17
Q

drugs with flushing SE

A

vanc, niacin, adenosine, CCB

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18
Q

SE coronary vasospasm

A

cocaine, amphetamines, triptans, ergotamine

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19
Q

torsades des pointes AE

A

K Channel blockers (class 3), Na channel blockers, macrocodes, haloperidol, chloroquine, protease inhibitors

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20
Q

thrombocytopenia SE

A

Heparin, cimetidine

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21
Q

agranulocytosis AE

A

clozapine, carbamazepine, colcicine, PTU, methimazole, dapsone

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22
Q

aplastic anemia

A

chloramphenicol, benzene, NSAID, PTU, methimazole

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23
Q

gray baby syndrome AE

A

chloramphenicol

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24
Q

hemolysis in G6PD def AE

A

isoniazid, sulfonamides, primaquine, ASA, ibuprofen, nitrofurantoin, dapsone, fava beans, napthalene

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25
Q

thrombosis AE

A

oral contraceptives

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26
Q

pulm fibrosis AE

A

amio, bleomycin, busulfan

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27
Q

cough AE

A

ACEi

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28
Q

psuedomembranous colitis

A

clinda, amox/amp

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29
Q

hepatic necrosis AE

A

halothane, acetaminophen, val acid

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30
Q

hep AE

A

isoniazid

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31
Q

tertiary adrenal insufficiency AE

A

corticosteroid withdrawal

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32
Q

gynecomastia AE

A

spironolactone, dig, estrogen, cimetidine, alc, ketoconazole, MJ

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33
Q

hot flashes AE

A

tamoxifen, clomiphene

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34
Q

hypothyroid AE

A

amio, li, sulfonamides

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35
Q

gout AE

A

diuretics (loop and thiazide), niacin, cyclosporine, pyraminamide

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36
Q

gingival hyperplasia AE

A

phenyoin, verapamil

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37
Q

osteoporosis AE

A

corticosteroids, hep

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38
Q

photosensitivity AE

A

sulfonamides, amio, tetracycline

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39
Q

SJS AE

A

carbamazepine, lamotrigine, allopurinol, phenytoin, phenobarbital, pen, ethosuximide, RASH, sulfa

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40
Q

drug induced lupus AE

A

SHIPP: sulfonamides, hydralazine, isoniazid, procainamide, phenytoin

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41
Q

tendinitis/cart damage AE

A

FQ

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42
Q

interstitial nephritis AE

A

NSAID, furosemide, ABX

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43
Q

Diabetes Insipidis AE

A

Li, Demeclocycline

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44
Q

Fanconi syndrome AE

A

tetracycline

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45
Q

hemm cystitis AE

A

cyclophosphamide

ifosfamide

46
Q

parkinson like syndrome AE

A

metoclopramide
antipsych
reserpine

47
Q

cinchonism AE

A

quinidine, quinine

48
Q

seizure AE

A

bupropion, imipenem/cilistatin, isoniazid, tramadol, metoclopramide, benzodiazepine/alc withdrawal

49
Q

tardive dyskinesia AE

A

antipsych

metroclopramide

50
Q

disulfiram like rxn AE

A

metro, cephalosporins (some), procarbazine, first gen sulfonylureas, disulfiram

51
Q

nephrotoxicity and neurotoxicity AE

A

AG, cisplatin, polymixins

52
Q

nephrotoxicity and ototoxicity AE

A

AG, vanc, loop, cisplatin

53
Q

AntiCholinergic effects AE

A

atropine, Tricyclic Antidep, H1 blockers, low potency neuroleptics

54
Q

cardiotoxicity and bone marrow supp AE

A

doxorubicin, daunorubicin

55
Q

acetaminophen OD

A

ammonium chloride

56
Q

salicylates OD

A

sodium bicarb

57
Q

amphetamines

A

N Acetylcysteine

58
Q

anticholinesterase, ogranophosphate OD

A

pralidoxine, atropine

59
Q

antimusc, antichol OD

A

physotigmine

60
Q

Dig OD

A

Anti-Dig Fab fragments

61
Q

iron OD

A

deferoxamine= Fe chelator

62
Q

lead OD

A

dimercaprol + Ca EDTA, succimer, penicillamine

63
Q

arsenic, mercury, gold OD

A

dimercaprol, succimer

64
Q

copper, arsenic, gold OD

A

penicillamine

65
Q

carbon monoxide OD

A

100% oxygen, hyperbaric oxygen

66
Q

methemoglobin OD

A

methylene blue and Vit C

67
Q

cyanide OD

A

hydroxocobalamin+thiosulfate, nitrates

68
Q

methanol, ethylene glycol OD

A

fomepizole, ethanol, diaylsis

69
Q

opioids OD

A

naltrexone, nalaxone

70
Q

benzo OD

A

flumazenil or supportive care

71
Q

tricyclic anti-dep OD

A

sodium bicarbonate

72
Q

heparin OD

A

protamine

73
Q

warfarin OD

A

Vit K

FFP

74
Q

tPA, streptokinase OD

A

aminocaprioc acid

75
Q

theophylline OD

A

BB

76
Q

what divides R and L atria?

A

septum primum and septum secundum

77
Q

fetal vessel oxygenation?

A

umbilical vein> ductus venosus> IVC> R atrium

78
Q

what causes ductus arteriosus to close?

A

infant breathe in–> inc oxygen blood in aorta–> dec prostaglandins–> close

79
Q

what causes foramen ovale to close?

A

infant breathe–> dec pulm vasc R–> higher LA pressure–> pushes septum premium against septum secundum

80
Q

pathway of generation of NE from tyrosine

A

phenylalanine–> tyrosine–> LDOPA–> Dopamine–> NE–> E

81
Q

tetralogy of fallot?

A

outflow obstrux- pulm stenosis
VSD
overriding aorta
RVH

82
Q

transposition of great vessels attach where?

A

aorta from RV

pulm trunk from LV

83
Q

which drugs improve survival in CHF?

A

ACEi, ARB, aldosterone antagonist, BB

84
Q

which drugs provide symptomatic relief?

A

diuretics, dig, vasodilators

85
Q

tx acute Heart failure?

A

NO LIP

nitrage, oxy, loop, ionotropic drugs

86
Q

3rd aortic arch?

A

common carotid, pro part of internal carotid a

87
Q

4th aortic arch?

A

L: arch of adult aorta

R: pro part of R subclavian a

88
Q

6th aortic arch?

A

pros part of pulm a, ductus arteriosus

89
Q

truncus arterioles gives rise to?

A

ascending aorta and pulm trunk

90
Q

bulbus cords gives rise to ?

A

smooth parts of L and R ventricles

91
Q

primitive atrium gives rise to?

A

trabeculated part of L and R Atria

92
Q

primitive V gives rise to?

A

trabeculated part of L and R Ventricles

93
Q

Primitive pulm vein gives rise to?

A

smooth part of L Atria

94
Q

L horn of sinus venosus gives rise to?

A

coronary sinus

95
Q

R Horn of sinus venous gives rise to?

A

smooth part of R atrium (sinus venarum)

96
Q

R common cardinal vein and R anterior cardinal vein gives rise to?

A

superior vena cava

97
Q

heart sound assoc with CHF

A

S3

98
Q

hear sound assoc with chronic HTN

A

S4

99
Q

jugular venous a wave

A

atrial contraction

100
Q

jugular venous c wave

A

Ventricular contraction

101
Q

jugular venous v wave

A

atria filling against closed tricuspid valve

102
Q

hemicholinium MOA

A

inihibts transport of choline into nerve by inhibiting Na cotransporter- normally brings choline and Na into the cell

103
Q

diastolic murmurs

A

tricuspid stenosis, mitral stenosis, aortic regurg, pulm regurg

104
Q

murmur heard best at left lateral deq position

A

mitral stenosis, mitral regurg, S3 and S4 left sided heart sounds

105
Q

bounding pulses, head bobbing, diastolic mumur

A

aortic regurg

106
Q

causes of aortic valve stenosis

A

bicuspid aortic vaclve, senile degenerative calcification, rheum heart disease, unicuspid aortic valve, syphilis

107
Q

weak pulse assoc murmur

A

aortic stenosis

pulsus parvus et tardus

108
Q

N acetylcysteine MOA

A

regen glutathione

tx= acetaminophen OD

109
Q

what enzyme is inhibited by fomepizole?

A

alcohol dehydrogenase

110
Q

antiarryth classes MOA

A

no
bad boy
keeps
clean

First Aid Pharm (9 decks)

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