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First Aid Pharm > DIT Days 3-4 > Flashcards

DIT Days 3-4 Flashcards

1
Q

cholinergic excess/organophosphate poisoning

A

DUMBBELSS

diarr, urination, miosis, bronchospasm, brady, excit skel muscle/CNS, lacrimation, salivation, sweat

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2
Q

endogenous agonist of opioid rec?

A

mu: endorphin
delta: enkephalin
kappa: dynorphin

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3
Q

uvula deviates R

A

L nuc ambiguus damage

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4
Q

branchial pouch 1:

A

mastoid air cell, middle ear cavity, eustachian tubes

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5
Q

branchial pouch 2

A

lining of palatine tonsils

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6
Q

branchial pouch 3

A

thymus, inferior parathyroid

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7
Q

branchial pouch 4

A

superior parathyroid glands

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8
Q

structures running through the cavernous sinus?

A

CN3, 4, 6, 5i, 5ii, internal carotid artery

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9
Q

alpha blocker with little effect on BP?

A

tamsulosin: selective alpha1 antag

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10
Q

non competitive inhibitor effect on Km and vmax

A

dec vmax, no change Km

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11
Q

competitive inhibitor effect on Km and vmax

A

no change on max and inc Km

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12
Q

CYP inhibitors

A

CRACK AMIGOS
cimetidine, ritonavir, amio, cipro, keotcona, acute alc use, macrolides, isoniazid, grapefruit juice, omeprazole, sulfonamides

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13
Q

what agents tx urge incontinence?

A

on the damn toilet

oxybutynin, tolterodine, darifenacin (and solifenacin), trolspium

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14
Q

dec km what happens to potency?

A

inc

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15
Q

change km what happened to efficacy?

A

no change

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16
Q

inc vmax what happens to efficacy?

A

inc

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17
Q

drugs with flushing SE

A

vanc, niacin, adenosine, CCB

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18
Q

SE coronary vasospasm

A

cocaine, amphetamines, triptans, ergotamine

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19
Q

torsades des pointes AE

A

K Channel blockers (class 3), Na channel blockers, macrocodes, haloperidol, chloroquine, protease inhibitors

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20
Q

thrombocytopenia SE

A

Heparin, cimetidine

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21
Q

agranulocytosis AE

A

clozapine, carbamazepine, colcicine, PTU, methimazole, dapsone

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22
Q

aplastic anemia

A

chloramphenicol, benzene, NSAID, PTU, methimazole

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23
Q

gray baby syndrome AE

A

chloramphenicol

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24
Q

hemolysis in G6PD def AE

A

isoniazid, sulfonamides, primaquine, ASA, ibuprofen, nitrofurantoin, dapsone, fava beans, napthalene

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25
thrombosis AE
oral contraceptives
26
pulm fibrosis AE
amio, bleomycin, busulfan
27
cough AE
ACEi
28
psuedomembranous colitis
clinda, amox/amp
29
hepatic necrosis AE
halothane, acetaminophen, val acid
30
hep AE
isoniazid
31
tertiary adrenal insufficiency AE
corticosteroid withdrawal
32
gynecomastia AE
spironolactone, dig, estrogen, cimetidine, alc, ketoconazole, MJ
33
hot flashes AE
tamoxifen, clomiphene
34
hypothyroid AE
amio, li, sulfonamides
35
gout AE
diuretics (loop and thiazide), niacin, cyclosporine, pyraminamide
36
gingival hyperplasia AE
phenyoin, verapamil
37
osteoporosis AE
corticosteroids, hep
38
photosensitivity AE
sulfonamides, amio, tetracycline
39
SJS AE
carbamazepine, lamotrigine, allopurinol, phenytoin, phenobarbital, pen, ethosuximide, RASH, sulfa
40
drug induced lupus AE
SHIPP: sulfonamides, hydralazine, isoniazid, procainamide, phenytoin
41
tendinitis/cart damage AE
FQ
42
interstitial nephritis AE
NSAID, furosemide, ABX
43
Diabetes Insipidis AE
Li, Demeclocycline
44
Fanconi syndrome AE
tetracycline
45
hemm cystitis AE
cyclophosphamide | ifosfamide
46
parkinson like syndrome AE
metoclopramide antipsych reserpine
47
cinchonism AE
quinidine, quinine
48
seizure AE
bupropion, imipenem/cilistatin, isoniazid, tramadol, metoclopramide, benzodiazepine/alc withdrawal
49
tardive dyskinesia AE
antipsych | metroclopramide
50
disulfiram like rxn AE
metro, cephalosporins (some), procarbazine, first gen sulfonylureas, disulfiram
51
nephrotoxicity and neurotoxicity AE
AG, cisplatin, polymixins
52
nephrotoxicity and ototoxicity AE
AG, vanc, loop, cisplatin
53
AntiCholinergic effects AE
atropine, Tricyclic Antidep, H1 blockers, low potency neuroleptics
54
cardiotoxicity and bone marrow supp AE
doxorubicin, daunorubicin
55
acetaminophen OD
ammonium chloride
56
salicylates OD
sodium bicarb
57
amphetamines
N Acetylcysteine
58
anticholinesterase, ogranophosphate OD
pralidoxine, atropine
59
antimusc, antichol OD
physotigmine
60
Dig OD
Anti-Dig Fab fragments
61
iron OD
deferoxamine= Fe chelator
62
lead OD
dimercaprol + Ca EDTA, succimer, penicillamine
63
arsenic, mercury, gold OD
dimercaprol, succimer
64
copper, arsenic, gold OD
penicillamine
65
carbon monoxide OD
100% oxygen, hyperbaric oxygen
66
methemoglobin OD
methylene blue and Vit C
67
cyanide OD
hydroxocobalamin+thiosulfate, nitrates
68
methanol, ethylene glycol OD
fomepizole, ethanol, diaylsis
69
opioids OD
naltrexone, nalaxone
70
benzo OD
flumazenil or supportive care
71
tricyclic anti-dep OD
sodium bicarbonate
72
heparin OD
protamine
73
warfarin OD
Vit K | FFP
74
tPA, streptokinase OD
aminocaprioc acid
75
theophylline OD
BB
76
what divides R and L atria?
septum primum and septum secundum
77
fetal vessel oxygenation?
umbilical vein> ductus venosus> IVC> R atrium
78
what causes ductus arteriosus to close?
infant breathe in--> inc oxygen blood in aorta--> dec prostaglandins--> close
79
what causes foramen ovale to close?
infant breathe--> dec pulm vasc R--> higher LA pressure--> pushes septum premium against septum secundum
80
pathway of generation of NE from tyrosine
phenylalanine--> tyrosine--> LDOPA--> Dopamine--> NE--> E
81
tetralogy of fallot?
outflow obstrux- pulm stenosis VSD overriding aorta RVH
82
transposition of great vessels attach where?
aorta from RV | pulm trunk from LV
83
which drugs improve survival in CHF?
ACEi, ARB, aldosterone antagonist, BB
84
which drugs provide symptomatic relief?
diuretics, dig, vasodilators
85
tx acute Heart failure?
NO LIP | nitrage, oxy, loop, ionotropic drugs
86
3rd aortic arch?
common carotid, pro part of internal carotid a
87
4th aortic arch?
L: arch of adult aorta R: pro part of R subclavian a
88
6th aortic arch?
pros part of pulm a, ductus arteriosus
89
truncus arterioles gives rise to?
ascending aorta and pulm trunk
90
bulbus cords gives rise to ?
smooth parts of L and R ventricles
91
primitive atrium gives rise to?
trabeculated part of L and R Atria
92
primitive V gives rise to?
trabeculated part of L and R Ventricles
93
Primitive pulm vein gives rise to?
smooth part of L Atria
94
L horn of sinus venosus gives rise to?
coronary sinus
95
R Horn of sinus venous gives rise to?
smooth part of R atrium (sinus venarum)
96
R common cardinal vein and R anterior cardinal vein gives rise to?
superior vena cava
97
heart sound assoc with CHF
S3
98
hear sound assoc with chronic HTN
S4
99
jugular venous a wave
atrial contraction
100
jugular venous c wave
Ventricular contraction
101
jugular venous v wave
atria filling against closed tricuspid valve
102
hemicholinium MOA
inihibts transport of choline into nerve by inhibiting Na cotransporter- normally brings choline and Na into the cell
103
diastolic murmurs
tricuspid stenosis, mitral stenosis, aortic regurg, pulm regurg
104
murmur heard best at left lateral deq position
mitral stenosis, mitral regurg, S3 and S4 left sided heart sounds
105
bounding pulses, head bobbing, diastolic mumur
aortic regurg
106
causes of aortic valve stenosis
bicuspid aortic vaclve, senile degenerative calcification, rheum heart disease, unicuspid aortic valve, syphilis
107
weak pulse assoc murmur
aortic stenosis | pulsus parvus et tardus
108
N acetylcysteine MOA
regen glutathione | tx= acetaminophen OD
109
what enzyme is inhibited by fomepizole?
alcohol dehydrogenase
110
antiarryth classes MOA
no bad boy keeps clean

First Aid Pharm (9 decks)

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