Drugs for Pulmonary Renal Syndromes Flashcards
What medications cause ANCA associated vasculitis
Hydralazine Propylthiouracil Methimazole Carbimazole Minocycline
In which populations should corticosteroid therapy be avoided
Immunocompromised DM Pts with infections Ulcers Cardiovascular conditions Psychiatric conditions
What are the indications for the use of cyclophosphamide
Malignant diseases (mostly lymphomas, leukemias)
Minimal change disease in children who did not respond to adrenocorticosteroid therapy
What is a contraindication for cyclophosphamide
allergy
urinary flow obstruction
What are the warnings and precautions associated with cyclophosphamide
Myelosuppression Immunosuppression Bone marrow failure Urinary and Renal Toxicity Pulmonary and Cardiac toxicity
What are the adverse reactions to cyclophosphamide
neutropenia febrile fever alopecia nausea/vomiting/diarrhea
What is the indication to use Rituximab
Non-hodgkin’s lymphoma
Chronic Lymphocytic leukemia
Rheumatoid Arthritis
What are the black box warnings associated with Rituximab
Fatal Infusion reactions
Tumor lysis syndrome
severe mucocutaneous reactions
PML
What are the adverse reactions to Rituximab
Lymphoid malignancies
RA: URI, nasopharyngitis, UTI
What drug must be avoided when taking Rituximab
Cisplatin
What are the indications for Azathioprine
prevent rejection of renal homotransplantation
Reduce S/S of RA (can use NSAID, Aspirin, Low dose glucocorticoids)
What are contraindications for azathioprine
Pregnancy
What are some warnings associated with azathioprine
Malignancy
When using immunosuppressive therapy what is the best rule of thumb to follow
prescribe at the lowest effective dose
