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Pharmacology > Drugs for Neurodegenerative Diseases > Flashcards

Drugs for Neurodegenerative Diseases Flashcards

1
Q

L-DOPA

A 
Increase DA synthesis
Dopamine precursor, crosses BBB
Oral, rapidly absorbed in SI
Short half-life
Tx: Parkinson's
SE: caused by peripheral conversion to NE--nausea, vomiting, anorexia, cardiac arrhythmias, orthostatic hypotension. Hallucinations, dyskinesia, mood changes, etc.
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2
Q

L-DOPA + carbidopa

A

Drug of choice for Parkinsons!
Increase DA synthesis
Tx: Parkinson’s

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3
Q

Entacapone

A

Increase DA synthesis
Inhibits COMT (decreases metabolism of LDOPA)
Only works in periphery
Tx: Parkinson’s

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4
Q

Apomorphine

A

DA receptor agonist
Only subcutaneous injection!
Tx: Parkinson’s
SE: nausea, vomiting, arrhythmias, postural hypotension, hallucinations, sleepiness

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5
Q

Bromocriptine

A

D2 agonist and D1 partial agonist
Activates D1 receptor
Oral
Tx: Parkinson’s

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6
Q

Pramipexole

A

D2 and D3 agonist
Activates D2 receptor
Oral
Tx: Parkinson’s

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7
Q

Ropinirole

A

D2 and D3 agonist
Activates D2 receptor
Oral
Tx: Parkinson’s

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8
Q

Amantadine

A

Moderately increases DA release, blocks cholinergic muscarinic receptors and NMDA receptors
Tx: Parkinson’s, bradykinesia, rigidity
SE: hallucinations, confusion, nausea, dizziness, rash on lower limbs.
Don’t prescribe to heart disease and glaucoma patients!
**Antiviral drug for treatment of Flu!

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9
Q

Benztropine

A

Antagonist of muscarinic cholinergic receptor
Tx: Parkinson’s, tremors, rigidity, NOT bradykinesia
SE: antimuscarinic effects

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10
Q

Trihexyphenidyl

A

Antagonist of muscarinic cholinergic receptor
Tx: Parkinson’s, tremors, rigidity, NOT bradykinesia
SE: antimuscarinic effects

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11
Q

Rasagiline

A

Decrease DA catabolism
Inhibitor of MAO-B
Tx: Parkinson’s

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12
Q

Selegiline

A 
Decrease DA catabolism
MAOI (B type inhibitor)
Decreases production of H2O2
Oral
Half-life= 7-9 hrs
Pee it out
Metabolized to Methamphetamine and amphetamine
Tx: Parkinson's
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13
Q

Donepezil

A

AChE inhibitor
Long acting
Metabolized by CYP3A4 and CYP2D6
Tx: Alzheimer’s

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14
Q

Galantamine

A

AChE inhibitor
Metabolized by CYP3A4 and CYP2D6
Tx: Alzheimer’s

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15
Q

Rivastigmine

A

AChE inhibitor
Short acting
Metabolized by plasma cholinesterase
Tx: Alzheimer’s

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16
Q

Tacrine

A 
AChE inhibitor
Short acting
Metabolized by CYP3A4 and CYP2D6
Tx: Alzheimer's
SE: hepatotoxicity
17
Q

Memantine

A

Blocks NMDA receptors
Derivative of Amantadine
Additive benefits when given with Donezepil
Tx: Alzheimer’s
SE: dizzy, headache, confusion, agitation, constipation

Pharmacology (10 decks)

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