Antipsychotics

Question 1

Chlorpromazine

Answer 1

Phenothiazine
Low potency
Blocks cholinergic (muscarinic) and alpha-adrenoceptor receptor (vasodilation) and H1 histamine receptor (weight gain and sedation)– causes SEs

Question 2

Fluphenazine

Answer 2

Phenothiazine
High potency
Slow release
Gluteal IM injection

Question 3

Thiothixene

Answer 3

Thioxanthene

Medium potency

Question 4

Haloperidol

Answer 4

Butyrophenone
High potency
Slow release
Gluteal IM injection
Blocks D2 receptors in pituitary to increase prolactin release and cause infertility and impotence

Question 5

Aripiprazole

Answer 5

Atypical
DA competitive partial agonist
Antagonizes serotonin receptors
Must be discontinued gradually
Blocks alpha-adrenoceptor, H1 histamine receptor

Question 6

Clozapine

Answer 6

Atypical
Selective antagonists for serotonin and dopamine receptors
Cholinergic muscarinic receptor, alpha-adrenoceptor block, H1 histamine receptor
SE: increased risk of agranulocytosis and leukopenia

Question 7

Olanzapine

Answer 7

Atypical
Selective antagonists for serotonin and dopamine receptors
Severe metabolic SEs (weight gain, increase Glc, chol, and TGs)
Cholinergic muscarinic receptor, alpha-adrenoceptor block, H1 histamine receptor

Question 8

Paliperidone

Answer 8

Atypical
Selective antagonists for serotonin and dopamine receptors
Major active metabolite of risperidone (CYP2D6)

Question 9

Quetiapine

Answer 9

Atypical
Selective antagonists for serotonin and dopamine receptors
Cholinergic muscarinic receptor, alpha-adrenoceptor block, H1 histamine receptor

Question 10

Risperidone

Answer 10

Atypical
Selective antagonists for serotonin and dopamine receptors
Gluteal IM injections

Question 11

Prochlorperazine

Answer 11

Antiemetic
Low potency antipsychotic
Blocks D2 receptor and H1 histamine receptor

Question 12

Promethazine

Answer 12

Antiemetic
Low potency antipsychotic
Blocks D2 receptor and H1 histamine receptor