Drugs For Neurodegenerative Diseases Flashcards by Kaden Robinson

Parkinsons

Death of dopaminergic (DA) neurons in substantia nigra

If DA is absent Ach has more dramatic stimulatory effect on striatum

90% of Da-ergic neurons in the striatum need to die before symptoms begin

How well did you know this?

Not at all

Perfectly

Parkinsons Symptoms

Bradykinesia- shuffling gait
Tremors
Muslce rigidity
Affective flattening

How well did you know this?

Not at all

Perfectly

Secondary Parkinsonism

Not PD but similar symptoms

Anti-psychotic medication can lead to extra pyramidal symptoms

How well did you know this?

Not at all

Perfectly

Drugs for PD moa / strategies

Dopamine system agonists

give levodopa (precursor to DA)
inhibit breakdowm of levodopa
agonize DA receptors

How well did you know this?

Not at all

Perfectly

Why not give DA for PD?

BBB endothelial cells metabolize DA via MAOs

How well did you know this?

Not at all

Perfectly

Actual Drugs for PD

Levodopa-carbidopa (parcopa)
Entacapone (comtan)
Levodopa-carbidopa-entacapome (stalevo)

How well did you know this?

Not at all

Perfectly

Levodopa-carbidopa (parcopa) moa

Provide DA precursor and (-) DOPA decarboxylase in perphery

How well did you know this?

Not at all

Perfectly

Entacapone (comtan) moa

Inhibits COMT in periphery

Which limits levodopa metabolism

How well did you know this?

Not at all

Perfectly

Levodopa-carbidopa-entacapome (stalevo) moa

Provide DA precursor and limit levadopa metabolism in periphery so more enters the brain

How well did you know this?

Not at all

Perfectly

Actual Drugs for PD pt 2

Apomorphine (apokyn)
Bromocriptine (parlodel)
Rotigotine (neupro)

How well did you know this?

Not at all

Perfectly

Apomorphine (apokyn) moa

DA receptor agonist

How well did you know this?

Not at all

Perfectly

Bromocriptine (parlodel) moa

DA receptor agonist

Used in adj with pt 1 drugs

How well did you know this?

Not at all

Perfectly

Rotigotine (neupro) moa

DA receptor agonist

Transdermal patch

How well did you know this?

Not at all

Perfectly

Alzheimer’s (AD) / tx strategies

Cholinergic dysfunction in memory centers of the brain

Inhibit AchE

How well did you know this?

Not at all

Perfectly

AD symptoms

Impaired memory
Confusion 
Inability to recognize family and friends
Aggression/depression
Psychoses

How well did you know this?

Not at all

Perfectly

Drugs for AD

Donepezil(Aricept)

Memantine (namenda)

Donepezil(Aricept) moa

AchE inhibitor

1 tx strategy for AD/ modest at best

Memantine (namenda) moa

NDMA (glutamte) receptor antagonist

Multiple Sclerosis (MS)

Antibodies target and destroy myelin in brain and spinal cord (CNS)

MS symptoms

Fatigue
Neuropathic pain
Heat sensitivity,spasticity
Dec balance
Visual impairment

Drugs for MS tx

Reduce circulating immune cells- reduce attack on myelin

Actual drugs for MS (relapsing-remitting amd Secondary-Progressive)

Interferon beta 1a (avonex)
Fingolimod (gilenya)
Glatiramer (copaxone)

Interferon beta 1a (avonex) moa

Cytokine drug- reduce pro inflammatory cytokines

Fingolimod (gilenya) moa

Small molecule that reduces number of circulating lymphocytes

Glatiramer (copaxone) moa

Mimics myelin basic protein (MBP) Decoy!

Actual drugs for MS (progressive-relapsing amd primary progressive)

Mitoxantrone (novantrone) | Alemtuzumab (lemtrada)

Mitoxantrone (novantrone) moa

Chemo agent, suppresses cell division

Alemtuzumab (lemtrada) moa

IgG monoclonal antibody- binds B and T cells which removes them from circulation