Drugs For Local And General Anesthesia Flashcards
Local anesthesia
Regional loss of pain
No loss of consciousness
Local Anesthetics moa
Na+ channel blockers
Non selective process
Side effects: Cns stimulation, anxiety,hypotension, dysthymias
Esters (local anesthetic)
Cocaine derivatives
Duration is 1-2 minutes
Benzocaine (americaine)
Procaine(novocain)
Amides (local anesthetic)
Longer duration of action
Lidocaine + epi (xylocaine)
Tx: anesthesia for short surgical procedures, labor, minor skin pain
Spinal and epidural injections
General Anesthesia
Loss of consciousness
Loss of sensation theough whole body-> paralysis
Balanced-multiple drugs
Stages of General Anesthesia
Loss of pain
Excitement and hyperactivity
Surgical anesthesia
Paralysis of medulla region in the brain
IV general anesthesic drugs
Propofol(diprivan) Fentanyl(sublimaze) Ketamine(ketalar) Diazepam(valium Lorazepam (Ativan)
Propofol(diprivan) moa
GABA receptor agonist
Most often used
Fentanyl(sublimaze) moa
Opioid receptor agonist
Superior analgesia
Ketamine(ketalar) moa
Glutamate (NDMA) receptor antagonist
Can respond to commands
Diazepam(valium
Lorazepam (Ativan) moa
GABA receptor agonist
Dissociative anesthesia or neuroleptanalgesia
Pt is conscious wirh no pain and can respond to commands
Fentanyl + droperdiol
Also with ketamine
Inhaled general anesthesics moa/drugs
Probably GABA agonism
Nitrous oxide-laughing gas
Isoflurane (furane)
Adverse effects: can cause malignant hyperthermia
Neuromuscular blocks drug
Succinylcholine (Anectine)
Blocks Ach receptors of neuromuscular junction
