Drugs for HF

Question 1

Sacubitril

Answer 1

NEP inhibitor, which delays degradation of ANP.

Used in tandem w/ Valsartan (which antagonizes AT1 receptors).

Question 2

Furosemide

Answer 2

Inhibits Na+-K+-2Cl- cotransporter.

Used to manage edema.

Must be concerned with toxicity due to sulfonamide.

Question 3

ARB suffix

Answer 3

-sartan

Question 4

Major side-effects of ACEI

Suffix

Answer 4

Cough, angioedema

-prils

Question 5

Pregnancy is a contraindication for:

Answer 5

ACEI

ARB

Question 6

DHF’s possible lethal outcome

Answer 6

Flash pulmonary edema

Question 7

Milrinone MOA

Answer 7

PDE 3 inhibitor

Question 8

Ivabridine

Answer 8

Inhibits funny channels in SA node to prolong diastole and slow HR.

Given to pts. with HF (<35% EF) and HR > 70 bpm.

Contraindicated in beta-blocker use.

Question 9

BiDil

Answer 9

Combo of isosorbide dinitrate (dilate vv.) and hydralazine (dilate aa.) given for chronic HF to be used by AA.

Only drug developed for one racial group.

Question 10

Losartan MOA

Answer 10

Non-peptide angiotensin II receptor antagonist

Question 11

Candesartan

Answer 11

ARB w/ irreversible binding

Question 12

Valsartan

Answer 12

ARB that is NOT a pro-drug

Question 13

Carvedilol should only be given if…

Answer 13

Pts. are clinically stable, but had a recent MI or reduction in EF

Question 14

Creatinine over 3.5 means you should not give:

Answer 14

ACEI or ARB

Question 15

Thiazides are not…

Answer 15

Potent enough to give on their own, must be used in combo w/ another med.

Question 16

Synthetic natriuretic peptide

Answer 16

Nesiritide

Question 17

Eplerenone

Answer 17

More selective aldosterone antagonist that Spironolactone and is approved for post-MI HF or in combo for Tx of HTN

Question 18

Sprinololactone MOA

Answer 18

Competitive antagonist of aldosterone

Question 19

If this is over 5.5, do not give ACEI or ARB?

Answer 19

K+

Question 20

Contraindication for Carvedilol

Answer 20

Bronchospasm