Anti-fungal, Anti-flu, Anti-TB drugs

Question 1

Amphotericin B MOA

Answer 1

Complexes w/ ergosterol and disrupts PM

Question 2

Flucytosine MOA

Answer 2

Produces FdUMP (inhibits DNA synthesis) and FUTP (inhibits RNA synthesis)

Question 3

Azoles MOA

Answer 3

Reduce ergosterol synthesis by inhibiting CYP450s

Question 4

Echinocandins MOA

Answer 4

Inhibit glucan synthesis (inhibits fungal CW production)

Question 5

Adamantanes MOA

Answer 5

Inhibit M2 ion channel of virus and inhibit the uncoating of RNA w/ infected hosts -> inhibits replication

Question 6

Isoniazid MOA

Answer 6

Inhibit mycolic acid synthesis

Question 7

Rifampin MOA

Answer 7

Inhibit RNA synthesis by binding beta-subunit of bacterial DNA-dependent RNA-pol.

Question 8

Amphotericin B coverage

Answer 8

Candida
Crypto-
Histo-
Blasto-
Coccidio-
Aspergillus
Mucor

Question 9

Flucytosine coverage

Answer 9

Narrow - C. neoformans

Question 10

Azoles coverage

Answer 10

Candida
C. neoformans
Dermophytes
Aspergillus

Question 11

Echinocandins coverage

Answer 11

Candida

Aspergillus

Question 12

Neuramidase inhibitors coverage

Answer 12

Influenza A and B

Question 13

Adamantanes coverage

Answer 13

Influenza A

Question 14

Amphotericin B adverse effects

Answer 14

Mostly immediate reactions from IV infusion.

Long-term: renal damage, anemia, seizures.

Question 15

Flucytosine adverse effects

Answer 15

Bone marrow toxicity w/ anemia, leukopenia, thrombocytopenia.

Question 16

Azoles adverse effects

Answer 16

Relatively non-toxic, but rarely mild GI sx.

Question 17

Echinocandins adverse effects

Answer 17

Well-tolerated

Question 18

Neuramidase inhibitor adverse effects

Answer 18

Psychiatric problems

Question 19

Adamantanes adverse effects

Answer 19

Nausea
Anorexia
Concentration problems
Insomnia

Question 20

Isoniazid adverse effects

Answer 20

Induced Hep.

Peripheral neuropathy

Question 21

Rifampin adverse effects

Answer 21

Harmless orange-colored sweat, urine, tears, etc.

Question 22

Suffixes for:

Echinocandins
Neuramidase inhibitors
Adamantanes

Answer 22

Echinocandins: -fungin
Neuramidase inhibitors: -vir
Adamantanes: -dine

Question 23

What the only member of the Imidazole subclass of the Azoles?

Answer 23

Ketoconozole

Question 24

Classic adverse effect of Ethanbutol

Answer 24

Ophthalmic problems

Question 25

What other first line drug is given in tandem with isoniazid and rifampin?

Answer 25

Pyrazinamide