Drugs for Fungal Infections of the Toenail & Fingernail

Question 1

Terbinafine**

Answer 1

Oral
-(250 mg po daily for 6 weeks for fingernail or 12 weeks for toenail
- risk of hepatotoxicity

Topical is Lamisil AT which is used for fungal skin infections

Question 2

Itraconazole

Answer 2

Sporanox
-oral
-200 mg po daily x 12 weeks or “pulse-dosing” (fingernails only): 200 mg BID x 1 week, 3 weeks off then repeat 1-week course

-BBW: avoid use in HF

Question 3

Ciclopirox

Answer 3

Loprox
topical
used QHS

• used in combo with orals; poor efficacy when used alone

Question 4

Tavaborole

Answer 4

Kerydin
topical oxaborole antifungal

-applied topically for 48 weeks

Question 5

Efinaconazole

Answer 5

Jublia
topical azole antifungal

• applied topically for 48 weeks