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CRP > Drugs for CHF > Flashcards

Drugs for CHF Flashcards

1
Q

What are the cardiotonic drugs?

A

Digitalis

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2
Q

What is the MOA of Digitalis?

A

Inotropic effect, inhibiting Na/K ATPase; causes increased Na > less Ca removal > increased myocardial contraction

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3
Q

What are the EKG manifestations of Digitalis?

A

Increased PR interval, shortened QT interval; Slight ST depression

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4
Q

When would you use Digitalis?

A

CHF as inotropic agent for systolic dysfunction; antiarrhythmic in AFib/PSVT (intentional 1 heart block); narrow therapeutic window

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5
Q

What are the side effects of digitalis?

A

Chronotropic effect, stimulating vagus nerve; decreases SA node rate (HR) and conduction to AV node (increase PR); Overdose > bradycardia and 1/2/3 heart block; Excess Ca > ectopic beats (PVCs); hypokalemia and hypercalcemia > increased toxicity; Hyperkalemia and hypermagnesium > reduced toxicity

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6
Q

What are the selective beta-1 agonists?

A

Dobutamine

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7
Q

What is the MOA of Dobutamine?

A

Increases cAMP activity > increased protein kinases and phosphorylation activity > increased Ca influx

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8
Q

When would you use Dobutamine?

A

Acute CHF

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9
Q

What are the side effects of Dobutamine?

A

Can develop tolerance with prolonged use

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10
Q

What are the Phosphodiesterase Inhibitors?

A

Milrinone, Inamrinone

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11
Q

What is the MOA of Milrinone?

A

Inhibits PD III, which increases cAMP activity > increased intracellular Ca; potent vasodilator > decreased preload and afterload and increased CO

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12
Q

When would you use Milrinone?

A

Short term in acute CHF

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13
Q

What are the side effects of Milrinone?

A

NV, arrhythmia, liver enzyme changes, thrombocytopenia

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14
Q

What is the MOA of Inamrinone?

A

Inhibits PD III, which increases cAMP activity > increased intracellular Ca; potent vasodilator > decreased preload and afterload and increased CO

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15
Q

When would you use Inamrinone?

A

Short term in acute CHF

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16
Q

What are the side effects of Inamrinone?

A

NV, arrhythmia, liver enzyme changes, thrombocytopenia

17
Q

What is the MOA of Diuretics?

A

Decrease excessive LVEDP without reducing SV

18
Q

When would you use diuretics?

A

Decrease pulmonary edema, preload, and pulmonary congestion

19
Q

What are the side effects of diuretics?

A

Can cause hypotension in excess

20
Q

What are the vasodilators?

A

Venodilators and Arteriolar dilators

21
Q

What is the MOA of venodilators?

A

Decrease preload > decreased venous return and pulmonary edema

22
Q

What is the MOA of arteriolar dilators?

A

Decrease afterload and PR and increase CO

CRP (10 decks)

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