Adrenergics-OLD Flashcards
What are the alpha agonists?
Norepinephrine, Phenylepherine, Methoxamine, Metaraminal, Phenylpropanolamine, Pseudoephendrine
What is the function of Norepinephrine?
Pressor. Increases TPR, systolic BP, diastolic BP, and mean BP. No change in HR
What is the function of Phenylephrine?
Pressor, decongestant, mydriatic
What is the function of Methoxamine?
Pressor
What is the function of Metaraminal?
Pressor; acts on Alpha-1, stimulates release of NE
What is the function of Phenylpropanolamine?
Decongestant
When would you use Norepinephrine?
For Hypotension
What are the side effects of the alpha adrenergics?
Anxiety, respiratory difficulty, forceful heartbeat, headache, hypertension, infiltration necrosis (IV), rebound nasal congestion
What are the alpha-2 agonist adrenergic drugs?
Clonidine
What is the function of Clonidine?
Induces hypotension, sedation, bradycardia; decreases sympathetics
What are the specific beta agonist adrenergic drugs?
Isoproterenol, Dobutamine
What are the functions of Isoproterenol?
Relaxes smooth muscle, vasodilates skeletal muscle, increases CO
What are the functions of Dobutamine?
Increases CO and SV without changing BP
When would you use Dobutamine?
Short-term treatment of cardiac decompression
What are the side effects of the specific beta agonist adrenergics?
Tachycardia
What are the specific beta-2 agonist adrenergic drugs?
Isoetharine, Metaproterenol, Terbutaline, Albuterol, Bitolterol
What are the side effects of the specific beta-2 agonist adrenergics?
Skeletal muscle tremor, hyperglycemia
What are the specific agonists?
Epinephrine, Dopamine, Ephedrine
What are the functions of Epinephrine?
Low dose: beta agonist, high dose: alpha and beta agonist
When would you use epinephrine?
To relieve bronchospasm, prolong local anesthetic
What are the functions of dopamine?
Low dose vasodilator, medium dose beta-1, high dose alpha-1
What are the functions of ephedrine?
Increases HR, CO, TPR, BP, bronchodilation
When would you use ephedrine?
Asthma, nasal congestion
What are the alpha blockers?
Phenoxybenzamine, Phentolamine
What are the functions of Phenoxybenzamine?
Decrease TPR, BP. Increase HR, CO, NE release
What are the functions of Phentolamine?
Decrease TPR, BP. Increase HR, CO, NE release
When would you use Phentolamine?
Short term control of hypertension in pheochromocytoma
What are the side effects of Phenoxybenzamine?
Postural hypotension, tachycardia, no sperm, no ejaculation
What are the side effects of Phentolamine?
Hypotension, tachycardia
What are the alpha-1 blockers?
Prazosin, Terazosin
What are the functions of Prazosin?
Decrease TPR, VR, BP, Preload
When would you use Prazosin?
Hypertension; Doxazosin is a longer-HL analog
What are the side effects of Prazosin?
Postural hypotension (maybe syncope), developed tolerance
How is Terazosin different from Prazosin?
Less potent, more specific, more water soluble, more BA, longer HL, than Prazosin
What are the Alpha-2 blockers?
Yohimbine