Drugs Cholinoceptor blockers Flashcards
Cholinoceptor blockers also called
Parasympatholytics/plegics
Two type of Parasympatholytics
Antimuscarinic
Antinicotinics
Name drugs that are antimuscarinic
Atropine
Scopolamine
Tropicamide
Ipratromine
name Depolarizing antinicotinic muscle relaxers
Succinylcholine and acetylcholine
name Non-depolarizing antinicotinic muscle relaxers
Derivatives of curare
cholineceptor blockers are agonist or antagonists
antagonists
antimuscarinic or antinicotinic
what are the 2 types of nicotinic antagonist (antinicotinic)
1) ganglion blockers
2) NMJ blockers(muscle relaxers)
what do ganglion blockers do and what category are they. why arent they used much?
category–> antinicotinic; nicotinic antagonist
not used much bc affect both SNS and PNS bc target all nicotinic receptors–> nicotinic neuronal and nicotinic muscular
difference between nicotinic neuronal and nicotinic muscular receptors
NN–> found in the CNS so both SNS and CNS; involved in communication btw post and preganglionic neurons
-have beta and alpha receptors
-THINK NEURAL SIGNALING WITH ANS AND CNS
NM–> located in the NMJ of skeletal muscle so communication btw neurons and muscle fibers
-Ach binding to these leads to muscle contraction
-THINK SKELETAL MUSCLE CONTRACTION
how do NMJ blockers work
also called muscle relaxers; block n-Ach at neuromuscular endplate so block Ach from binding and blocks muscle contraction
name the 2 different types of muscle relaxants
also called NMJ blockers
depolarizing(agonist) and non depolarizing(antagonist)
how do depolarizing muscle relaxants work
antinicotinic receptors so depolarizes muscle endplate so cell not able to receive the Ach and contract then relax(tetanus)–> instead just get one contraction then not able to repolarize to contract again
describe how succinylcholine works and what it is
depolarization acetylcholine muscarinic receptor AGONIST because bind to mAch
really good agonist bc does not get broken down at the NMJ; instead gets broken down in the plasma very fast(10 minutes)
describe the difference between succinylcholine phase 1 and phase 2 block
Phase 1 block- bind to receptor and causes continuous depolarization which causes relaxation. Lack of repolarization
Phase 2 Block(deeper block)- give drug for extended amount of time then muscle not reacting well to it and you will get repolarization
how do nondepolarization muscle relaxants work
competitive antagonist bc block Ach from binding so no signal
excessive concentration of nondepolarizing NMJ blockers cause what
a channel blockade so get a paralyzed patient
what is the reversal of nondepolarization NMJ blockers
sugammadex–> surrounds drug so cannot interact with receptor
neostigmine–> make more acetylcholine available
use of depolarizing NMJ blockers
intubation and used to use it for electroconvulsion therapy