Drugs - Cardiac Flashcards

1
Q

verapamil

A

ccb (diphenylalklamine). V site of calcium channel. antiarrhythmic.

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2
Q

diltiazem

A

ccb (benzothiazepine). D site of calcium channel. antiarrhythmic.

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3
Q

nifedipine

A

ccb (dihydroxypyridine). N site of calcium channel. more specific to vascular SM compared to cardiac Ca channels. not for antiarrhythmia.

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4
Q

-olol

A

beta blocker

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5
Q

sodium nitroprusside

A

vasodilator. liberates NO. rapid, so given in hypertensive emergencies.

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6
Q

nitric oxide pathways

A

cGMP…MLCP;

Ca-dependent K channels to hyperpolarize cell

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7
Q

angina agents

A

nitrates
beta-blockers
ccb

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8
Q

nitroglycerin

A

rapid nitrate for acute angina. 5 min half life.

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9
Q

isosorbide dinitrate

A

nitrate for chronic angina. 1 hour half life.

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10
Q

isosorbide 5-mononitrate

A

nitrate for chronic angina. 2 to 4 hour half life.

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11
Q

heart failure agents

A
diuretics
beta blocker
ACE inhibitor
ARB
vasodilator
digoxin (glycoside)
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12
Q

enalapril

A

ace inhibitor for cardiac failure

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13
Q

metoprolol

A

beta blocker for cardiac failure. Beta1 selective.

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14
Q

digoxin

A

inhibits Na/K ATPase. buildup of Na prevents extrusion of Ca in the Na/Ca exchanger. buildup of Ca increases contractions

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15
Q

quinidine

A

na-channel blocker. class Ia. primary arrhythmia syndromes.

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16
Q

procainamide

A
na-channel blocker. class Ia. ventricular tachycardia.
metabolite is a k-channel blocker.
17
Q

disopyramide

A

na-channel blocker. Class Ia

18
Q

lidocaine

A

na-channel blocker. Class Ib

19
Q

mexiletene

A

na-channel blocker. Class Ib

20
Q

propafenone

A

na-channel blocker. Class 1c

21
Q

flecainide

A

na-channel blocker 1c. a fib, CPVT

22
Q

amiodarone

A

k-channel blocker(class III). all arrhythmias.

23
Q

sotalol

A

non selective beta blocker. also k-channel blocker. VT, a fib.

24
Q

dronedarone

A

k-channel blocker

25
Q

dofetilide

A

k-channel blocker

26
Q

ivabradine

A

rate-slowing agent

27
Q

phenytoin

A

na-channel blocker. antiepileptic.