Drugs and mutations

Question 1

Function of olaparib

Answer 1

PARP inhibitor

Question 2

Target of Cetuximab

Answer 2

Erb-1 for colon/ rectum cancers

Question 3

Function of Crizotinib

Answer 3

NSCLC Targeting EML4-ALK fusion found on tumors of adenocarcinoma

Question 4

Target of Vemurafinib

Answer 4

Melanoma BRAF

Question 5

Function of rituximab

Answer 5

Binds to the CD on B cells

Question 6

Blinatumomab

Answer 6

BiTE cells that can be used against CD19 on B cells

Question 7

Oxi4503

Answer 7

VDF preventing tubulin function

Question 8

Bevacizumab

Answer 8

Anti VEGF

Question 9

What occurs in H-Ras mutation?

Answer 9

G –> T transversion causing G to bind with A instead.

Question 10

What is the mutation in retinoblastoma?

Answer 10

N-Myc mutation

Question 11

What is the function of philedelphia chromosome?

Answer 11

Tyrosine kinase activity causing cell proliferation and decrease DNA repair by production of IL3.

Question 12

What is the mutation in burkitts lymphoma

Answer 12

IgH- Myc t(8;14)

Increased proliferation

Question 13

What is the mutation and function of non-hodgkins follicular lymphoma?

Answer 13

IgH- BCl2 t(14;18)

Decreased apoptosis

Question 14

What does BRAF mutaiton in melanoma result in?

Answer 14

Increase in MAPK pathway.

Question 15

What does the EGFR mutation in NSCLC result in?

Answer 15

EML4-ALK fusion causing increase in EFGR receptor