046 Metastatic disease and oncology drug development

Question 1

What is E-cadherin?

Answer 1

responsible for cell to cell adhesion to help assemble and maintain epithelial sheets.

Question 2

What does N-cadherin do?

Answer 2

promotes migration of cells

Question 3

How do PARP inhibitors work?

Answer 3

1. PARP inhibitors increase single strand breaks
2. This forms toxic dna double strand breaks
3. In BRCA1/2 mutated cells, they lose any ability to repair
4. Normal cells, BRCA allows for HR function so DNA repaired.