042 Haemopoiesis and haematological malignacies

Question 1

Which has a better cure rate, hodgkins or non-hodgkins lymphoma?

Answer 1

hodgkins lymphoma

Question 2

What does the cytokine erythropoietin stimulate?

Answer 2

anti-apoptosis of red blood cells and increase in RBC progenitors.

Question 3

What does the cytokine G-CSF stimulate

Answer 3

neutrophil half life extension during infections

Question 4

How do you cure CML?

Answer 4

Complete replacement of haematopoietic cells with HLA match donor

Question 5

What does philadelphia chromosome result in?

Answer 5

increased proliferation

decreased apoptosis

Question 6

What does PML-RARa result in?

Answer 6

Differentiation block

Question 7

What does IgH-Myc result in?

Answer 7

Increase proliferation

Question 8

What does IgH-Bcl2 result in?

Answer 8

decrease apoptosis

Question 9

WHich B cell lymphoma responds better to cytotoxics?

Answer 9

Burkitss lymphoma

Question 10

Describe the Ras pathway

Answer 10

RAS - GDP is inactive
SOS replacing GDP with GTP acitvates it
Promote proliferation
GTPases such as NF-1 changes GTP-Ras back to GDP-Ras

Question 11

How does loss of NF1 result in AML or ALL?

Answer 11

No negative feedback on the Ras proliferation pathway

Question 12

What would you treat a woman who has CML with if she is at child bearing age?

Answer 12

inteferon alpha (antiproliferative cytokine)

Question 13

Which chromosome is the lambda light chain located on?

Answer 13

Chromosome 22

Question 14

Which chromosome is the kappa light chain located on?

Answer 14

Chromosome 2

Question 15

What are BH3 mimetics?

Answer 15

Small molecules that activate apoptosis. inhibits BCl2, which leads to apoptosis.