040 Tumor drug resistance Flashcards
1
Q
What pathway does BRAF gene stimualte?
A
MAPK pathway
2
Q
What mutation is found in non-smoking lung cancer?
A
EGFR mutation
3
Q
What is the first line of treatment for Kidney cancer? how does it work?
A
VEGF antibody – not selective – variable response
VHL in kidney cancer is mutated, this expresses HIF1a
HIF1a will bind to VEGF receptor.
4
Q
Which resistant mutation in BRAF mutant melanoma causes treatment resistance?
A
NRAS mutation
