037 Tumor vasclature and therapeutic strategies

Question 1

activate or inhibit tumor angiogenesis:

1. VEGF-A
2. Angiostatin
3. Thrombospondin
4. Endostatin
5. PDGF
6. bFGF
7. sVEGR1

Answer 1

1. activate
2. inhibit
3. inhibit
4. inhibit
5. activate
6. activate
7. inhibit

Question 2

Why is there poor drug uptake in tumors even though they have high vessel permeability?

Answer 2

High intersitial pressure

Question 3

Describe tumor regulation by HIF1

Answer 3

HIF1 binds to HIF1beta subunit

This binds to hypoxic element on promoter e.g. VEGF, PDGF, bFGF

Question 4

Name a vascular disrupting agent and describe its mechanism

Answer 4

OXI4503

• -> Tubulin binding agent
• -> prevent endothelial cell division
• -> endothelial cells fall off basement membrane
• -> exposed to platelets
• -> vascualr shut down
• -> tumor necrosis.

However, tumor persists at the broder.

Question 5

What is VDA combination therapy?

Answer 5

When you combine VDA with cytotoxic drug.
Cytotoxic drug acts at peripheral rim
VDA acts at the centre hypoxic.

Question 6

Which tumors are VDA combination therappy non-responsive in

Answer 6

Pancreatic and prostate cancer

Question 7

Name an anti-VEGFR

Answer 7

bevacizumab