DRUGS AND BONES Flashcards

1
Q

What derivative of arachidonic acid is often present at inflammatory sites?

A

Cox 2

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2
Q

What is the first step of treatment of RA?

A

NSAIDS and other analgesics (opioids)

These only treat the symptoms

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3
Q

What are side effects of cox 2 selective inhibitors?

A

Paradoxically they can can thrombosis

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4
Q

What are DMARDs?

A

Disease modifying anti-rheumatic drugs

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5
Q

What is the mechanism of methotrexate?

A

Competitive inhibition of dihydrofolate reductase

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6
Q

How often is methotrexate taken?

A

Once weekly

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7
Q

What are the side effects of methotrexate?

A
Mouth ulcers
Nausea
Bone marrow suppression
Interstitial lung disease
Renal failure
Hepatitis
Acute cutaneous reactions
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8
Q

What must you screen for before giving an anti-TNF medication?

A

TB as it can be re activated whilst on these drugs

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9
Q

What do most drugs involved in treatment musculoskeletal disease target?

A

Inflammatory cells and inflammatory mediators

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