Drugs Acting on the Thyroid Flashcards
What is T4 known as?
Thyroxine
What percentage of T4 and T3 are bound to plasma proteins?
99%
What percentage of Thyroxine is produced in the thyroid gland?
100%
What percentage of T3 is produced in the thyroid gland?
About 20%
Which is the biologically active form, T3 or T4?
T3
What happens to T4 in the tissue?
It is deiodinated in tissue to T3.
Approximately how much T4 is converted to T3 in the tissues?
What are 3 types of tissue where this takes place?
- About 80%
- Liver, kidney, muscle
Which enters cells more rapidly, T3 or T4?
T3
Which has a more rapid onset of action, T3 or T4?
T3
Which one is 3-5x more potent than the other, T3 or T4?
T3
T/F: Thyroid decreases metabolic rate in most tissues.
False - it increases metabolic rate.
T/F: Thyroid increases oxygen consumption in most tissues.
True
