Drugs acting at the ANS - Cholinergic Receptors

Question 0

Drugs acting on cholinergic synapses can act on.

Answer 0

Ganglia,
Muscarinic receptors,
Neuromuscular junction,
Enhance cholinergic transmission.

Question 1

Which is longer presynaptically?

Answer 1

Parasympathetic nerve.

Question 2

Action of nicotine.

Answer 2

Dependant on dose.

Question 3

Low dose nicotine.

Answer 3

Stimulation of sensory receptors.

Question 4

High dose.

Answer 4

Depolarisation blockade.

Question 5

Sympathomimetic effects of nicotine.

Answer 5

CVS effects, BP, heart rate and blood pressure.

Question 6

Parasympathomimetic effects of Nicotine.

Answer 6

GIT movement, HCl in stomach.

Question 7

Central effects of nicotine.

Answer 7

Nausea, arousal, high.

Question 8

Where can you find nicotinic neural receptors?

Answer 8

Ganglia, adrenal medulla, sensory nerve endings.

Question 9

Agonists of nicotinic neural.

Answer 9

Ach and nicotine.

Question 10

Antagonists of nicotinic neural.

Answer 10

Hexamethonian, trimethaphan.

Question 11

Nicotinic muscle receptor agoinsts.

Answer 11

Suxamethonium, decamethonium.

Question 12

Nicotinic muscle receptor antagonists?

Answer 12

Tubocurarine, atracurium, mivacurium, vecuronium. (Transmission block). MUSCLE relaxants!

Question 13

Miscarinic agonists can be described as being…

Answer 13

Parasympathomimetics.

Question 14

Type of muscarinic agonists at the heart.

Answer 14

M2.

Question 15

Pilocarpine.

Answer 15

A partial Muscarinic agonist, used to treat Glaucoma. Contract iris smooth muscle. Weak effects in GIT and heart.

Question 16

Bethanocol.

Answer 16

Bladder and bowel stimulation.

Question 17

Agonist at Muscarinic receptors for smooth muscle.

Answer 17

Cause GIT and bronchoconstriction.

Question 18

Muscarinic Antagonists.

Answer 18

Parasympatholytics.

Question 19

Muscarinic antagonists examples.

Answer 19

Atropine and derivatives. Iprtropium, Hycosine, Dcyclomine.

Question 20

Atropine poisoning.

Answer 20

Eye dilation, photphpobia, inhibition of micturition, Tachycardia, CNS - restlessness, delirium, coma, convulsions.

Question 21

Antidote for atropine poisoning.

Answer 21

Anticholinesterase - neostigmine, physostigmine.

Question 22

Uses of atropine.

Answer 22

Adjunct for anesthesia,
Antidote for anticholinesterase poisoning,
Bradycardia,
Antispasmodic.
Reduction of diarhhea (lomotil),
Parkinsons (benztropine).

Question 23

Significant about atropine.

Answer 23

Non selective inhibitor of muscarinic receptors.

Question 24

Main indiactions of atropine.

Answer 24

Bradycardia and anticholinesterase poisoning.

Question 25

Hycosine indication.

Answer 25

Gut spasms

Question 26

Ipratropium indication.

Answer 26

Bronchoconstriction.

Question 27

Benztropine indication.

Answer 27

Parkinsons disease.

Question 28

Types of receptors found in cholinergic nerves?

Answer 28

Muscarinic and Nicotinic.

Question 29

What are the two types of drugs that work at the Neuromuscular junction?

Answer 29

Non depolarising and depolarising. | Inhibitors of acetylcholine synthesis or release.

Question 30

What drugs can cause Nicotinic receptor stimulation?

Answer 30

Nicotine, DMPP, epibatidine, Suxamethonium, decamethonium.

Question 31

If you stimulate muscarinic receptors do you get pumped up or do you relax?

Answer 31

You relax.

Question 32

M3 actions.

Answer 32

Miosis, Salivation, Bonchoconstriction, GIT motilty, Bladder wall contraction.

Question 33

A selective M2 agonist can be used for?

Answer 33

Dysrhytmias.

Question 34

Tropicamide indication.

Answer 34

Dilation of pupil.

Question 35

Muscarine receptor agonists.

Answer 35

ACh, Muscarine, pilocarpine, carbachol and bethanechol.

Question 36

Muscarine antagonists.

Answer 36

Atropine and derivatives.

Question 37

Name drugs that prevent ACh synthesis.

Answer 37

Vesamicol, | Hemicholium.

Question 38

Drugs that inhibit ACh release?

Answer 38

Botulinum and bungaratoxin.

Question 39

How would I cure botulinum poisoning?

Answer 39

Anti toxin, enema.

Question 40

Drugs which are Non depolarising blockers at the NMJ?

Answer 40

Cura's.

Question 41

Depolarising blockers at NMJ.

Answer 41

Suxamethonium, decamethonium.

Question 42

Side effects of depolarising blockers?

Answer 42

Bradycardia, | Prolonged paralysis.

Question 43

Stuff that enhance cholinergic transmission.

Answer 43

Cholinesterase inhibitors or anticholinesterases.

Question 44

Examples of irreversible antivholinesterase?

Answer 44

In insecticides. Ecothipate.

Question 45

Reversible anticholinesterases.

Answer 45

Stigmines, edrophonium.

Question 46

Use of anticholinesterase?

Answer 46

Treat myasthenia gravis.