DRUGS Flashcards
Selegeline
Monoamine inhibitor, used to treat early stage Parkinson’s, depression and dementia
found in dopaminergic nerve terminals
Flumazinil
reverses benzodiazepine
GHB (Date rape drug)
causes sedation by increasing amount of GABA available
Fenfluramine
stimulates the release of serotonin and inhibits its reuptake (has been used as an appetite suppressant in the treatment of obesity)
MDMA
ecstasy
causes NE and serotonin transporters to run backwards releasing neurotransmitter into synapse/extracellular space
Neostigmine
block the breakdown of ACh, prolonging its actions in the synaptic cleft
treatment of myasthenia gravis
Tetanus toxin
inhibits the release of Glycine and GABA at inhibitory neurons, resulting in dis-inhibition of cholinergic neurons, which causes permanent muscle contraction.
Amphetamine
reverses transporter so pumps out transmitter and blocks reuptake (DA & NE)
Cocaine and Methylphenidate (Ritalin)
block DA reuptake into terminals. More DA in synaptic cleft – extended action on postsynaptic neuron.
Physostigmine
Inhibits cholinesterase, used to treat Alzheimer’s disease due to its function in increasing cholinergic function
Scopolamine
muscarinic receptor antagonist
suppresses theta waves and impairs spatial learning
Baclofen
Agonist of GABA b receptor
used as a muscle relaxant to reduce spasticity e.g. in Huntington’s disease
Phencyclidine
NMDA receptor blocker
produces symptoms associated with schizo (hallucinations)
Quinidine
antiarrythmic
lowers conduction velocity
Which extends the refractory period
common side effects of SSRI
Diarrhea, reduced libido, dry mouth, headache
