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MS4 - Psychiatry > Drugs > Flashcards

Drugs Flashcards

1
Q

Prefrontal cortex functions

A

Logic
Reason
Personality

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2
Q

Amygdala functions

A

Fear

Emotion

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3
Q

Nucleus accumbens functions

A

Reward centre

Dopamine dependent

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4
Q

Heroin dependence time

A

8-12 wks

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5
Q

EtOH dependence time

A

4 wks

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6
Q

Opioid actions

A

Mu opioid receptor agonist

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7
Q

Morphine / codeine

A

Opiate

Full agonists

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8
Q

Tramadol

A

Opioid

Full agonist

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9
Q

Fentanyl

A

Opioid

Full agonist

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10
Q

Methadone

A

Opioid
Full agonist
Used to wean addiction

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11
Q

Buprenorphine

A

Opioid
Partial agonist
Used to wean addiction

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12
Q

Opioid effects as dose increases (and opposite as decreases hence withdrawal)

A 
Analgesia
N and V, Constipation, Pruritis
Euphoria
Sedation
Respiratory depression
Death
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13
Q

Alcohol

A

GABA agonist

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14
Q

Benzodiazepines

A

GABA agonist

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15
Q

Pregabalin / Gabapentin

A

GABA agonist

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16
Q

Why must GABA agonists be gradually reduced and not suddenly stopped

A

Can cause seizures due sudden influx

17
Q

Amphetamines

A

DA agonist

18
Q

Cocaine

A

DA agonist

19
Q

Base (Crack) Cocaine

A

DA agonist

20
Q

MDMA / ecstasy

A

5HT, DA, NA agonist

21
Q

Nicotine action

A

ACh agonist

22
Q

Psychedelic drug examples

A

LSD (acid)

Psilocybin (magic mushrooms)

23
Q

Psychedelic drug action

A

5HT-2a agonist

24
Q

Ketamine

A

NMDA antagonist

25
Q

Cannabis action

A

Cannabinoid receptor 1/2 agonist

26
Q

Why is cannabis particularly bad for children < 20 years old?

A

Prevents dendritic pruning process

MS4 - Psychiatry (15 decks)

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