Drugs

Question 1

Prefrontal cortex functions

Answer 1

Logic
Reason
Personality

Question 2

Amygdala functions

Answer 2

Fear

Emotion

Question 3

Nucleus accumbens functions

Answer 3

Reward centre

Dopamine dependent

Question 4

Heroin dependence time

Answer 4

8-12 wks

Question 5

EtOH dependence time

Answer 5

4 wks

Question 6

Opioid actions

Answer 6

Mu opioid receptor agonist

Question 7

Morphine / codeine

Answer 7

Opiate

Full agonists

Question 8

Tramadol

Answer 8

Opioid

Full agonist

Question 9

Fentanyl

Answer 9

Opioid

Full agonist

Question 10

Methadone

Answer 10

Opioid
Full agonist
Used to wean addiction

Question 11

Buprenorphine

Answer 11

Opioid
Partial agonist
Used to wean addiction

Question 12

Opioid effects as dose increases (and opposite as decreases hence withdrawal)

Answer 12

Analgesia
N and V, Constipation, Pruritis
Euphoria
Sedation
Respiratory depression
Death

Question 13

Alcohol

Answer 13

GABA agonist

Question 14

Benzodiazepines

Answer 14

GABA agonist

Question 15

Pregabalin / Gabapentin

Answer 15

GABA agonist

Question 16

Why must GABA agonists be gradually reduced and not suddenly stopped

Answer 16

Can cause seizures due sudden influx

Question 17

Amphetamines

Answer 17

DA agonist

Question 18

Cocaine

Answer 18

DA agonist

Question 19

Base (Crack) Cocaine

Answer 19

DA agonist

Question 20

MDMA / ecstasy

Answer 20

5HT, DA, NA agonist

Question 21

Nicotine action

Answer 21

ACh agonist

Question 22

Psychedelic drug examples

Answer 22

LSD (acid)

Psilocybin (magic mushrooms)

Question 23

Psychedelic drug action

Answer 23

5HT-2a agonist

Question 24

Ketamine

Answer 24

NMDA antagonist

Question 25

Cannabis action

Answer 25

Cannabinoid receptor 1/2 agonist

Question 26

Why is cannabis particularly bad for children < 20 years old?

Answer 26

Prevents dendritic pruning process