Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuro Block 4 > Drugs > Flashcards

Drugs Flashcards

1
Q

How does Levodopa become DA?

A

L-aromatic amino acid decarboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sinemet

A

Levodopa + Carbidopa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Entacapone

A

COMT inhibitor –> stops metabolism of Levodopa in periphery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Selegiline

A

Mono-amine oxidase (MAO) inhibitor

Blocks MAO-A and MAO-B (this metabs. DA):

smooths “on-off”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pramipexole

A

DA receptor agonist (D2 specific)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Trihexyphenidyl

A

muscarinic antagonist

used to treat Parkinson’s

Corrects ACh:DA balance… mech unclear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Symmetrel (Amantadine)

A

NMDA receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pentamidine

A

binds DNA

does not cross BBB

use for trypanosoma brucei stage 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Suramin

A

(mech unknown)

does not cross BBB

toxic!!

Stage 1 Trypanosoma brucei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Benznidazole and Nifurtimox

A

mech: increases ROS, via NADH-dependent dehydrogenase

does not cross BBB

Stage 1 trypanosoma brucei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Arsenicals (Melarsoprol)

A

Use for stage 2 rhodesiense trypanosoma brucei (ASS)

very toxic/death!

crosses BBB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Eflornithine

A

inhibits ornithine decarboxylase

–static (doesn’t kill)

less toxic

Stage 2 trypanosoma brucei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Eflornithine + Nifurtimox

A

Eflornithine (-static) crosses BBB

Nifurtimox (-cidal) does not cross BBB

Late stage 2 trypanosoma brucei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Sodium stibogluconate + Meglumine antimonate

A

used for trypanosoma cruzi = Chagas disease (leishmaniasis)

stops glycolysis and FA beta-ox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Liposomal Amphotericin B

A

Use for tyrpanosoma cruzi = Chagas disease

Only visceral leishmasiasis (splenomegaly)

use for resistant strains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Sulfadiazine + Pyrimethamine

A

folate antagonist combo

Toxoplasma gondii (toxoplasmosis)

17
Q

Spiramycin

A

macrolide (binds 23s subunit of 50S ribosome blocking protein synthesis)

Use for pregnant mother with toxoplasma

not so toxic to fetus

18
Q

miltefosine

A

New drug for treatment of primary amebic meningoencephalitis

only one available

Neuro Block 4 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions