Drews

Question 1

CNS vs. PNS proteins

Answer 1

Mostly the same!

CNS: PLP (ProteoLipidProtein)

PNS: P0 (P0 prot), PMP-22

Question 2

Myelin basic protein

Answer 2

• acts in the cytoplasm to keep the membranes very close together

Question 3

ProteoLipidProtein (PLP) vs P₀

Answer 3

PLP: transmembrane protein that attaches membranes in CNS

P0 does the same thing in the PNS

Question 4

Demyelination vs. Dysmyelinating disease

Answer 4

Both are CNS and PNS diseases

Demyelination = acquired (MS (CNS), Guillain-Barre syndrome (PNS))

Dysmyelination = inherited (Leukodystrophies)

Question 5

Alternative pre-mRNA splicing of the _____ gene can lead to pathology.

Answer 5

myelin basic protein

Question 6

Cortical Synaptic Plasticity has two basic elements…

Answer 6

If presynaptic and postsynaptic neurons are active simultaneously, then the synapse is strengthened.
“Neurons that fire together wire together.”

If presynaptic and postsynaptic activities are not linked, then the synapse is weakened.
“Neurons that fire out of sync loose their link.”