Drugs

Question 1

Linezolid mechanism

Answer 1

Xs bacterial protein synthesis

Question 2

LMWH mechanism

Answer 2

Xs factor Xa

Question 3

Heparin mechanism

Answer 3

Activate antithrombin and factor X
Inactivates thrombin

Question 4

Clopidogrel mechanism

Answer 4

Xs ADP receptors on platelets

Question 5

Warfarin mechanism

Answer 5

Xs vitamin K epoxide reductase

Question 6

Test for clindamycin resistance

Answer 6

D test
To figure out if erythromycin resistant S aureus is sensitive to clindamycin
Bc of inducible resistant - plasmid of Saureus alters 50S ribosome so can be resistant to both clinda + erythro

Question 7

Botox mechanism

Answer 7

Binds receptors on motor nerve terminals -> NO pre-synaptic release Ach

Question 8

Abatacept mechanism

Answer 8

DMARD
MHC receptor antagonist

Question 9

Anakinra mechanism

Answer 9

IL-1 receptor antagonist

Question 10

-imab or -umab DMARD mechanism

Answer 10

TNF-alpha Abs

Question 11

How does MRSA develop its penicillinase-stable abx resistance

Answer 11

Genetic mutation mecA - alters penicillin binding protein - allows hydrolyze the abx

Question 12

Mechanism of vanco + vanco resistance

Answer 12

Vanco: Xs cell wall synthesis by binding cell wall precursor
Resistance: alter peptidoglycan subunit

Question 13

Mechanism of erythromycin/tetracycline resistance

Answer 13

Active efflux pumps

Question 14

Mechanism denosumab

Answer 14

mAb Xs RANKL
Blocks osteoclast maturation

Question 15

Treat red man syndrome

Answer 15

Benadryl + ranitidine
After allergy sx resolve, restart vanc at 50% original rate