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AKT > Drugs 1 > Flashcards

Drugs 1 Flashcards

1
Q

BB common S/E (4)

Contraindications (4)

A

bronchospasm
cool peripheries
sleep disturbance
erectile dysfunction

sick sinus syndrome
uncontrolled heart failure
asthma
concurrent verapamil use

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2
Q

Cautions (2) and contraindications to ACEi (1)
Specialist advice should be sought before starting ACE inhibitors in patients with?

A

Renovascular disease
Hereditary of idiopathic angioedema
Aortic stenosis CI

A potassium >= 5.0 mmol/L

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3
Q

Ivabradine MOA

SE (4)

A

Blocks funny ion current in the SAN and reduced HR

visual effects
headache
bradycardia
heart block

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4
Q

Amiodarone monitoring
Prior to treatment
Every six months

A

TFT, LFT, U&E, CXR prior to treatment
TFT, LFT every 6 months

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5
Q

Amiodarone adverse effects (10)
Hints:
x4 organs
appearance
ECG
HR

A

thyroid dysfunction
corneal deposits
pulmonary fibrosis/pneumonitis
liver fibrosis/hepatitis
peripheral neuropathy, myopathy
photosensitivity
‘slate-grey’ appearance
thrombophlebitis and injection site reactions
bradycardia
lengths QT interval

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6
Q

Inhibitors of P450 causes INR to?
Inducers of the P450 system causes the INR to

A

increase
decrease

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7
Q

P450 inducers (therefore reduce efficacy of other drugs due to increased breakdown)

BullShit CRAP GPS

A

Barbiturates
St John Warts
Carbamezapine
Rifampacin
Alcohol (chronic)
Phenytoin
Griseofluvin
Phenobarbitol
Sulfonylureas + smoking

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8
Q

P4550 inhibitors (therefore increase toxicity risk)

SICKFACES.COM

A

Sodium valproate
Isoniazid
Cipro
Ketoconazole
Fluconazole
Acute alcohol
Chloramphenicol
Erythro
Sulfonamides
Cimetidine
Omeprazole
Metronidazole

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9
Q

Loop diuretics adverse effects (6)

A

Low Na, K+, Mg, Ca
Low BP
Renal impairment
Ototoxicity
Gout
Increased BM

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10
Q

Which anti-anginal can cause ulcers?

A

Nicorandil

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11
Q

Nicorandil SE (3)

CI

A

headache
flushing
skin, mucosal and eye ulceration
gastrointestinal ulcers including anal ulceration

left ventricular failure

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12
Q

Adverse effects of carbimazole (2)

A

Agranulocytosis
Crosses the placenta but can be used in low doses in pregnancy

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13
Q

SE GLP1 mimetics (2)

A

weight loss
severe pancreatitis

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14
Q

Pioglitazone SE

CI

A

weight gain
liver impairment
fluid retention
bladder cancer

CI heart failure

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15
Q

SGLT2 SE (4)

A

urinary and genital infection
fournier’s gangrene
increased risk of lower limb amputation
weight loss

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16
Q

Orlistat SE (2)

A

Faecal urgency/ incontinence
Flatulence

17
Q

AZT adverse effects (3)

A

Bone marrow depression
Pancreatitis
Increased risk of non-melanoma skin ca

18
Q

AZT interacts with?

A

Allopurinol - lower doses of AZT should be used in this case

19
Q

Bisphosphonates adverse effects (4)

A

Oseophagitis + ulcers
Osteonecrosis of the jaw
Increased risk of stress fractures of proximal femoral shaft
Low calcium

20
Q

Denosumab SE (2)

A

diarrhoea
dyspnoea

21
Q

Common causes of drug induced lupus (2)

A

Procainamide
Hydralazine

22
Q

Adverse effects hydroxychloroquine

A

Bulls eye retinopathy (can result in severe and permanent visual loss)

23
Q

Leflunomide DMARD CI

A

pregnancy - contraception is needed whilst on it and for 2 years after for women and 3 months for men

24
Q

Leflunomide monitoring (3)

A

FBC, LFT and BP

25
Q

Leflunomide adverse effects (3)

A

Lung and liver issues
HTN

26
Q

MTX adverse effects (5)

A

mucositis
myelosuppression
pneumonitis
pulmonary fibrosis
liver fibrosis

27
Q

MTX monitoring

A

FBC, U+E, LFTs before starting, weekly until stabilised, then every 2-3 months

28
Q

Sulfasalazine (4)

A

Rash
Oligospermia
Heinz body anaemia
Interstitial lung disease

29
Q

Prednisolone (5)

A

Cushingoid
Osteoporosis
Impaired glucose tolerance
HTN
Cataracts

30
Q

Penicilliname can exacerbate which condition?

A

Exacerbation of myasthenia gravis

31
Q

Etanercept

A

Demyelination
Reactivation of TB

32
Q

Prostaglandin analogues (latanoprost)
SE (2)

A

Brown pigmentation of the iris
Increase eyelash length

33
Q

Sympathomimetics e.g brimonidine in the rx of glaucoma
Avoid taking with?
SE

A

MAOI or TCAs
Hyperaemia

34
Q

Pilocarpine SE (3)

A

Headache
Constricted pupil
Blurred vision

35
Q

SE rashes, oligospermia, headache, Heinz body anaemia, megaloblastic anaemia, lung fibrosis

A

Sulphasalazines

36
Q

Adverse effects of omeprazole (4)

A
  1. Low sodium
  2. Low magnesium
  3. Osteoporosis
  4. Increased risk of c.diff

AKT (52 decks)

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