Drug Treatment For Parkinsons

Question 1

Current treatments aim to

Answer 1

Restore DA/ACh imbalance

Reduce cholinergic transmission
Boost dopaminergic transmission

Question 2

Alternative routes of drug administration to circumvent dyskinesia

Answer 2

Rotigotine patchy effective as mono therapy in early PD

Duo-dopa: intraduodenal pump to provide L-Dopa infusion

Question 3

Surgical approaches used in PD

Answer 3

Used in medically refractory patients only

Question 4

Type of surgryin PD

Answer 4

Thalamotomy (tremor-dominant cases)

Pallidotomy(improves rigidity and bradykinesia)

Subthalamontomy (same as pallidotomy +LIDS)

Question 5

Disadvantage of surgery

Answer 5

Irreversible

Risk of visual impairment