Drug Table

Question 1

2 MAO-B selective Inhibitors:

Answer 1

• Selegiline

- Rasagiline

Question 2

MAOI + ___ –> Hypertensive Crisis

MAOI + ___ –> Serotonin Syndrome

Answer 2

• Tyramine

- SSRI

Question 3

2 COMT inhibitors:

Answer 3

• Entacapone

- Tolcapone

Question 4

1st line treatment for Parkinson’s (Combo)

Answer 4

Levodopa + Carbidopa (limit peripheral conversion)

Question 5

Only drug for Huntington’s Chorea

Mechanism?

Answer 5

Tetrabenzine

-prevent monoamine release

Question 6

What class can cause TD, EPS, NMS?

Answer 6

Antipsychotics

Question 7

Drug with most metabolic risk of all antipsychotics:

Answer 7

Clozapine

Question 8

Common mechanism of all antipsychotics

Answer 8

D2 receptor antagonism

Question 9

Additional mechanism of 2nd gen ‘Atypical’ antipsychotics:

Answer 9

5HT2a receptor antagonism

Question 10

2 Groups of 2nd gen antipsychotics and their side effects:

Answer 10

‘Pines’ –> sedation

‘Dones’ –> EPS

Question 11

What is EPS:

Answer 11

Extrapyramidal symptoms: drug-induced movement disorders

1. Dystonia: continuous spasm, muscle contractions
2. Akathisia: motor restlesness
3. Parkinsonism: rigidity, bradykinesia, tremor
4. Tardive dyskinesia: jerky, irregular

Question 12

Drug used to diagnose myasthenia gravis

Answer 12

Edrophonium

Question 13

Drug used to confirm Horner’s Syndrome

Answer 13

Cocaine

Question 14

Prostaglandin analog mechanism of action:

Answer 14

Increase uveoscleral outflow

Question 15

Carbonic anhydrase inhibitor mechanism of action:

Answer 15

Reduce aquous humor production

Question 16

Lithium uses

Answer 16

• Anti-manic
• Mood-stabilizing (bipolar)
• Long-term Cluster headache prevention

Question 17

Antidote for methanol and ethylene glycol poisoning

Answer 17

Fomepizole - blocks alcohol dehydrogenase

Question 18

Hallucinogen mechanism of action:

Answer 18

5HT2a receptor agonist

Question 19

Fluoxetine and Paroxetine side effects not shared w/ other SSRIs:

Answer 19

Potent P450 inhibition

Question 20

2 Atypical Antidepressants and their mechanisms:

Answer 20

Buproprion: NDRI
Mirtazapine: 5HT2a antagonist, SRI

Question 21

2 Major active metabolites of morphine

Answer 21

M6 (more potent/active)

M3 (little affinity)

Question 22

3 Common opioid side effects:

Answer 22

1. Miosis
2. Constipation
3. Respiratory depression

Question 23

Opioid mechanism of action:

Answer 23

Mu- opioid receptor agonist

Question 24

Opiods w/ GI effect:

Answer 24

Loperamide

Diphenoxylate

Question 25

Synthetic codeine analog:

Answer 25

Tramadol

Question 26

Opioid antagonists:

Answer 26

Naloxone

Naltrexone

Question 27

Benzodiazepine mechanism of action:

Answer 27

GABAa agonist: binding between a1 and y2 subunits

Question 28

Benzo w/ shortest half-life:

Answer 28

Midazolam, 1.9 hours

Question 29

Benzo used to prevent alcohol withdrawl symptoms:

Answer 29

Lorazepam

Question 30

Benzo used to induce sleep:

Answer 30

Triazolam

Question 31

Benzodiazepine antidote:

Answer 31

Flumazenil

Question 32

2 Barbituate drugs:

Answer 32

Thiopental

Phenobarbitol

Question 33

Anxiolytic without marked sedation

Answer 33

Busiprone

Question 34

[Benzodiazepines/Barbituates] have life-threatening withdrawal symptoms

Answer 34

Barbituates (and alcohol)

Question 35

Nitrous Oxide mechanism

Answer 35

NMDA receptor antagonist

Question 36

What is Propofol infusion syndrome?

Answer 36

IV infusion for several days –>

1. Metabolic acidosis
2. Rhabdomyolysis
3. Heart and renal failure
4. Lower BP
5. Bradycardia
6. Death

Question 37

Rocuronium mechanism and antidote

Answer 37

Competitive ACh blocker (non-depolarizing)

Sugammadex - complexes w/ rocuronium

Question 38

What is Hofman elimination?

Answer 38

Spontaneous, non-enzymatic degradation

Question 39

2 Types of local anesthetics

Answer 39

• ‘Esters’

- ‘Amides’

Question 40

Local anesthetic with highest cardiac toxicity potential

Answer 40

Bupivicaine