Behavioral Flashcards
What is APGAR?
A - appearance (color) P - pulse G - grimace (reflex irritability) A - Activity (muscle tone) R - Respiration
Used to predict likelihood of immediate survival (of neonates)
Normal = 8-9
Post Partum Major Depression occurs in ___ of new mothers, within ___ of child birth, and can persist ___
10%
1 month
1 year
Criterion for premature and very premature birth
Premature: 37 Weeks
Very premature: 32 Weeks
4 Necessary infant reflexes necessary for survival
- Rooting: touch cheek –> turn toward nipple
- Palmar Grasp: grip any object put in palm
- Moro: limb extended when child is startled
- Babinski: dorsiflexion of toes when sole is stroked
3 Spheres of Development:
- Motor
- Social
- Verbal/Cognitive
How does development tend to occur (progress)? From ___ to ___
- Cephalad to caudal
- Central to peripheral
- From self to others
- From understanding to expressing
Stranger anxiety starts at ___
9 months
Social smile starts at ___
12 weeks
Separation anxiety starts at age ___
But ____always comes first
Separation Anxiety Disorder Starts at age ___
Late in first year
Object permanence comes first
7 years: school phobia/refusal
Babinski reflex disappears at ___
1 year
What milestone at age 2?
Say “No!”
Terrible Twos
Gender identify by age ___
3 years
Play progression:
Cooperative by age ___
Solitary –> parallel –> associative –> cooperative
4 years
Year 6 Milestones
- “Superego”
- Morality
- Empathy
- Lying is wrong
- Finality of death
Rett’s Disorder Characteristics:
- 4 Years of normal functioning
- Hand wringing
- Breathing problems
- Intellectual impairment
- Ataxia
- Motor and social declines,
- X-linked
Universality of death by age ___
Morality by age ___
9 years
12 years
Body image and popularity ideas by age ___
15 years
3 Predisposing factors for teen pregnancy
- Depression
- Poor school achievement
- Divorced parents
Selective Mutisum usually starts at age ___
6 years
Phonological vs Articulation disorders
Phonological: leaves out or misplaces speech sounds
Articulation: unable to make necessary motor movements for accurate speech. ex: lisp
Separation Anxiety Disorder Characteristics
- School phobia or refusal
- Starts at 7 years/stressful life event/anxious family
Autism Spectrum Disorder Findings:
- Seen before age 3
- No finger pointing (theory of mind)
- Larger head circumference (overgrowth during first year)
- More common in boys
5 Stages of Dying:
Denial Anger Bargaining Depression Acceptance
Bereavement (normal grief) vs. Complicated Bereavement (abnormal)
- Both have initial shock and denial
- Both include sadness and crying
- Abnormal involves suicidal thinking or hallucinations
Schizophrenia definition:
“Split Mind”
Behavior vs. thought content divergence
Hallmark symptom of schizophrenia:
Psychosis: impairment in reality testing
List 12 Symptoms of Psychosis
- Illusion
- Hallucination
- Ideas of reference
- Delusions
- Loss of ego boundaries
- Alogia
- Echolalia
- Thought Blocking
- Neologisms
- Circumstantiality
- Tangentiality
- Loose associations
Difference between Illusion vs Hallucinations
Illusion: misinterpretation of real external stimuli
Hallucinations: sensory perceptions not generated by external stimuli
What is false conviction that one is subject of attention by other people?
Ideas of reference
Delusions:
Most common type?
- False beliefs
- Not correctable by logic or reason
- Delusions of persecution most common
Loss of ego boundaries:
Not knowing where one’s mind and body end and those of others begin
Alogia:
- Lack informative content in speech
- Mute or speaks few words
“I’m very sure I’ve got the cure and I’m not pure”
Echolalia:
- Repeating statements of others
- Associating words by their sounds, not meanings
“I have to take my…..”
Often because of ___
Thought blocking
hallucinations
“I’m fatigloo”
Neologisms
Circumstantiality vs Tangentiality
Circumstantiality: responds to questions, but presenting voluminous details
Tangentiality: beginning logically, getting further from the point, fail to answer question
“I drive a brown car. So i like brown snickers and the sun is really nice today.”
Loose associations
- Loss of logical meaning
- No linked associations
- Illogically jumps from one subject to another
Differentiate Schizophrenia vs Medical Delirium
Schizophrenia= no clounding of consciousness: alert, oriented
Schizophrenia DSM-5 Criteria
A. Characteristic Symptoms (2+)
B. Social/Occupational dysfunction: at least 1 of work, interpersonal, self care
C. Duration: at least 6 months w/ 1 month of symptoms
D. Schizoaffective and Mood Disorder exclusion
E. Substance/general medical condition exclusion
5 Schizophrenia characteristic symptoms:
- Delusions
- Hallucinations
- Grossly disorganized or catatonic behavior
- Negative symptoms
- Disorganized speech
3 Phases of Schizophrenia:
- Prodromal: prior to 1st psychotic break
- Psychogic/Active: loss of touch w/ reality
- Residual: period between psychotic episodes, in touch w/ reality, but doesn’t behave normally
Schizophrenia age of onset in men vs women
Men: 15-25
Women 25-35
Enlargement of what brain structure(s) in Schizophrenia?
Lateral and third ventricle
Brain density change in what brain structure(s) in Schizophrenia?
Lower density –> smaller
Hippocampus, amygdala, parahippocampal gyrus
What happens in frontal lobe in Schizophrenia?
Hypofrontality: decreased use of glucose
Dopamine Hypothesis of Schizophrenia:
Glutamate Hypothesis of Schizophrenia
- Excessive DA activity in MESOLIMBIC tract
- Hypoactivity of NDMA receptor in brain
2 Neuronal Pathways in Schizophrenia (positive/negative symptoms)
Positive: Glu-GABA-Glu-DA
Pathology: high DA in mesolimbic
Negative: Glu-GABA-Glu-GABA-DA
Pathology: low DA in mesocortical
Brief Psychotic Disorder
Schizophrenia symptoms
1-29 days LESS than 1 month
Schizophreniform Disorder
1-6 Months of Schizophrenia symptoms
Schizoaffective Disorder
Schizophrenia + mania and/or depression
All effective antipsychotics for Schizophrenia block ___ receptors in ___ DA pathway
D2
mesolimbic
DSM-5 Criteria for Neurodevelopmental Disorder
New name for ADHD
- Start before age 12
- Symptoms in multiple (2+) settings
- Must cause social disability
- 6+/9 Symptoms (inattention or hyperactive/impulsive)
- 6 Months
Versions of ADHD
- Combined
- Inattentive
- Hyperactive/impulsive
- Other specified, or unspecified
2 neurotransmitter genes most commonly associated w/ ADHD
Dopamine system
Noradrinergic system
ADHD __ symptoms tend to persist greater than ___ symptoms
Inattentive > hyperactivity/impulsivity
High dopamine/noradrinergic activity leads to ___
Very high leads to ___
Hypervigilant
Very high –> Psychosis
Low dopamine/noradrinergic activity leads to ___
Very low leads to ___
ADHD
Very low –> Schizophrenia (-) symptoms
In ADHD brains, selective pruning happens (earlier/later)
Later
3 Nonaddictive ADHD Drugs:
Side effects?
Atomoxetine (NRI)
Guanfancine ER a2 agonist
Clonidine ER a2 agonist
Less efficacy than stimulants
Often sedating
May lower BP
Class of ADHD drugs that has greatest efficacy is ___
Adverse effects?
Stimulant class
Risk of addiction
Too much –> paranoia
Stunt growth, weight loss (low appetite)
1st line ADHD treatment for preschool, children and adolescents, and adults
Preschool: behavioral therapy
Children and adolescents: Slow release Methylphenidate (MPH)
Adults: Nonaddictive (Atomoxetine, Modafinil, Ganfacine ER, Clonidine ER)
a2 Agonist mechanism of action for ADHD
Norepi a2 receptor: increase signal strength –> increase signal to noise ratio –>make glutamate function more efficient
Most common co-occuring disorder with ADHD:
Anxiety
Functional MRI finding in ADHD
Hypoactive Anterior Cingulate
3 Spheres of functioning:
- Social
- Academic
- Occupational
Personality traits are [immutable/circumstantial/modifiable] risk for suicide
Immutable
Risk traid for suicide includes
Ideation
Intention
Plan
What religions are at increased risk for suicide?
- Jewish or protestant
- Highest in protestant
Highest risk demographic for suicide:
Middle aged
White/Caucasian
Male
Top 3 leading causes of death for adolescents 15-19
- Accidents
- Homocide
- Suicide
Age and gender pattern for suicide risk
- Increases substantially after 55
- Decrease for old women
- Increase for old men
- Men ALWAYS higher risk than women
Top suicide method in US vs. elsewhere
US: firearms
Elsewhere: hanging
[Short/long] allele for serotonin transporter gene (SERT) associated with increased MDD and suicide risk
Short allele (ss) –>highest risk
Long allele (l/l) –> protective
Antidepressents [raise/lower] risk of suicide for what group of people?
Raise
24 or younger
Why increased suicide risk initially after being put on antidepressants?
-Increased energy and clear thinking improve before lifting of depressed mood –> More energy to act on suicidal thoughts
Greatest predictor of suicide risk:
Past violence
DSM-5 Major Depressive Disorder Criteria:
- 5+/9 Symptoms during 2-week period (at least 1 is depressed mood or loss of interest/pleasure)
- Symptoms cause distress or impairment in functioning
- Not attributable to physiological effects
SIG E CAPS
Sleep disturbance Interest/pleasure reduction Guilt, worthlessness Energy loss, fatigue Concentration/attention impairment Appetite changes Psychomotor symptoms Suicide Ideation
How to differentiate normal sadness vs. depression?
S.W.A.G Have at least one of the following in depression: Suicidality Weight loss Anhedonia Guilt
Atypical Depression likely findings:
- Weight gain, hypersomnia
- Leaden paraysis, carb cravings, rejection sensitivity
Medical conditions that mimic depression:
- Hypothyroidism –>tired
- Cushing’s
- Anemia –>tired
- Vitamin deficiency (B12, Folate)
- Obstructive sleep apnea –> poor brain perfusion at night
2 Biological Theories of Depression:
- Monoamine deficinecy
- Monoamine receptor excess
-Reality= combination of both
(Genetic/Environmental) factors more important in depression
Environmental
Functional Neuroanatomy in MDD:
- Hypoactive dorsolateral prefontral cortex
- Hyperactive amygdala
Gender difference in MDD
- Lifetime prevalence: women > men
- Women more likely to seek help
2 Common comorbidities of MDD:
- Substance abuse
- Generalized anxiety
3 Frontline treatment classes of MDD:
SSRI
SNRI
NDRI
Less severe side effects than MAOIs and TCAs
Increasing cortisol in brain does what to make depression more likely?
Decrease brain neurotrophic factors
What is Delay of Reinforcement Gradient?
- Individuals w/ ADHD are MORE sensitive to IMMEDIATE reinforcement
- LESS sensitive to DISTAL reinforcement
- Compared to normally developing individuals
Oppositional Defiant Disorder (ODD) Criteria:
How to define severity?
- 4+ Symptoms (3 groups: Angry/Irritable, Argumentative/Defiant, Vindictive) for 6+ Months
- Negative Impact
- Not during course of other disease (psychotic, depressive)
- Severity based on number of settings (1, 2, 3+)
Conduct Disorder (CD) Criteria:
Violate norms or rights of others
- 3+ symptoms for 12+ months (agression, destruction, deceit/theft, violate rules)
- Functional impairment
- If 18+, criteria not met for Antisocial personality disorder
Limited prosocial emotions is:
Specific manifestation of Conduct Disorder
-2+ findings for 12+ months in multiple relationship/ssettings
Symptoms:
1. no remorse/guilt
2. no empathy
3. unconcerned about performance
4. shallow/deficient affect
Development impairment characteristics of Autism (4)
- No babble or coo by 12 months
- No gesture (point, wave, grasp) by 12 months
- Doesn’t say single words by 16 months or 2-word phrases by 24 months
- Loss of language or social skills at any age
Asperger’s Syndrom is Autism with high ___
IQ
Diagnosis of Autism based on:
- Autism Diagnostic Interview-R (ADI-R)
- Observation (home, school, video analysis)
3 Criteria for Intellectual Disability Diagnosis:
- IQ
Academic level achievement in Mild vs Moderate ID:
Mild: 6th grade, minimal supervision
Moderate: 2nd grade, under supervision
Examples of “essential” vs “associated” feature of Autism:
Essential: repetitive behavior, flapping, body rocking
Associated: self-injury, aggression, pica
3 Diagnostic criteria for Pica
- > 1 month eating non-nutritive substancces
- Eating is inappropriate for developmental level
- eating is not culturally sanctioned
Medication use in Autism
~27% of children take >1 med
Increase use of meds with age
CAM treatment decreases w/ age