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Block 5 > Drug resistance > Flashcards

Drug resistance Flashcards

1
Q

Enterobacteriaceae, Pseudomonas, Acinetobacter have ?

A

Reduction in porin expression

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2
Q

Give what for ESBL?

A

Carbapenems

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3
Q

MRSA resistance

A

mecA

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4
Q

VRSA resistance

A

MIC>16

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5
Q

VRE mechanism

A

VRE with Van A resistance

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6
Q

ESBL can form resistance to

A

monobactams, 3rd gen ceph

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7
Q

Encodes by enterbac, mediates resistance to lower gen cephalosporins, most penicillins, beta lactamase inhibitor / beta lactam combos

A

AmpC

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8
Q

AMP C mutants

A

Citrobacter and Enterobacter

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9
Q

Aminoglycoside

A

change in OM

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10
Q

Glycopeptides resistance

A

D-ala-D-X

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11
Q

Macrolides

A

Methylation

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12
Q

Oxazolidinones

A

Reduced binding to active site

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13
Q

Quinolones

A

Reduced binding active site

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14
Q

Tetracyclines

A

New membrane transporter

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Block 5 (9 decks)

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