Antimicrobials 2 Flashcards
Aminoglycosides MOA
irreversible inhibitor of protein synthesis
- results in production of aberrant proteins (misread mRNA)
- Premature release of mRNA
Aminoglycosies primary spectrum
Aerobic gram neg
Pseodomonas
Enterobac
Acinectobacter
AMinoglycosolides limited spectrum
Gram positive organisms
Gentamycin -treats gram positive infection
Aminoglycosies only treat
Anerobic
As opposed to ahminoglycosides , tetracycline do what
Bind reversely rather than irreversibly to 30S
Tetracyclines hit
MRSA Resistant gram neg Anerobes Chlamydiae, mycoplasma, Rickettsiae Some protozoa
Tetracyclines is decreased with
calcium , iron and mag
tetracycline has good. . .
tissue distribution
Don’t give what during pregnancy
tetracycline
tetra- sounds like teratogen
Linezolid MOA
binds 50S . . . distorts binding of TRNA
3 macrolides
Mad McCLusky is an ACE !!
Azithromycin
Clarithromycin
Erythromycin
Macrolides MOA
reversible binding to 50S inhibiting bac protein synth
Give macrolides with
a typical PNA
Main adverse effect with macrolides
Prolonged QT
Lincosamide is in what family
Clindamycin
CLindamycin for
gram positive
MRSA and Staph A
Anaerobes
No activity against gram negatives
Clinda
Clinda adverse rxns
C. diff
DNA topoisomeraseases
Fluoroquinones
Fluroquinones MOA
inhibits bacterial DNA synthesis
Fluroqunione spectrum
Gram neg: cipro
Gram pos: levoflox, moxiflox
Good bioavailability
Metronidazole (metallic taste)
MOA: reduces nitro group
created short lives free radicals (Direct DNA damage)
Metronidazole works on
Anerobic bacteria : particularly gram neg
Parasites
Rifampin
MOA : inhibits RNA poly
Sulfonamides
MOA: compete with p-aminobenzoic acid prevents folic acid synthesis
works on broad range of gram pos and gram neg
PZA
analogue of nicotinamide
