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Block 5 > Antimicrobials 2 > Flashcards

Antimicrobials 2 Flashcards

1
Q

Aminoglycosides MOA

A

irreversible inhibitor of protein synthesis

  • results in production of aberrant proteins (misread mRNA)
  • Premature release of mRNA
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2
Q

Aminoglycosies primary spectrum

A

Aerobic gram neg

Pseodomonas
Enterobac
Acinectobacter

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3
Q

AMinoglycosolides limited spectrum

A

Gram positive organisms

Gentamycin -treats gram positive infection

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4
Q

Aminoglycosies only treat

A

Anerobic

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5
Q

As opposed to ahminoglycosides , tetracycline do what

A

Bind reversely rather than irreversibly to 30S

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6
Q

Tetracyclines hit

A 
MRSA
Resistant gram neg
Anerobes
Chlamydiae, mycoplasma, Rickettsiae
Some protozoa
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7
Q

Tetracyclines is decreased with

A

calcium , iron and mag

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8
Q

tetracycline has good. . .

A

tissue distribution

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9
Q

Don’t give what during pregnancy

A

tetracycline

tetra- sounds like teratogen

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10
Q

Linezolid MOA

A

binds 50S . . . distorts binding of TRNA

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11
Q

3 macrolides

A

Mad McCLusky is an ACE !!

Azithromycin
Clarithromycin
Erythromycin

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12
Q

Macrolides MOA

A

reversible binding to 50S inhibiting bac protein synth

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13
Q

Give macrolides with

A

a typical PNA

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14
Q

Main adverse effect with macrolides

A

Prolonged QT

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15
Q

Lincosamide is in what family

A

Clindamycin

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16
Q

CLindamycin for

A

gram positive

MRSA and Staph A
Anaerobes

17
Q

No activity against gram negatives

A

Clinda

18
Q

Clinda adverse rxns

A

C. diff

19
Q

DNA topoisomeraseases

A

Fluoroquinones

20
Q

Fluroquinones MOA

A

inhibits bacterial DNA synthesis

21
Q

Fluroqunione spectrum

A

Gram neg: cipro

Gram pos: levoflox, moxiflox

Good bioavailability

22
Q

Metronidazole (metallic taste)

A

MOA: reduces nitro group

created short lives free radicals (Direct DNA damage)

23
Q

Metronidazole works on

A

Anerobic bacteria : particularly gram neg

Parasites

24
Q

Rifampin

A

MOA : inhibits RNA poly

25
Q

Sulfonamides

A

MOA: compete with p-aminobenzoic acid prevents folic acid synthesis

works on broad range of gram pos and gram neg

26
Q

PZA

A

analogue of nicotinamide

Block 5 (9 decks)

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