Drug Interactions: drug-drug

Question 1

Warfarin and NSAIDs

Answer 1

• BLEEDING
• Warfarin is an anticoagulant- prevent/treat blood clots + SE: bleeding
• NSAIDs can damage stomach lining, resulting in bleeding.
• NSAIDs ex: Ibuprofen, Naproxen, Aspirin

Question 2

Warfarin and Antibiotics

Answer 2

antibiotics increase bleeding risk associated with warfarin

Question 3

Oral contraceptives and Antibiotics

Answer 3

Antibiotics can decrease the effect of oral contraceptives, which increases the likelihood of contraceptive failure and increases risk of pregnancy.

Question 4

Nitrates and PDE-5 inhibitors

Answer 4

• both drugs dilate blood vessels
• taken together: blood pressure drops dangerously low lvl
• PDE-5 inh: any of the : “-afil”

Question 5

Lithium and Diuretics

Answer 5

toxicity if taking diuretics

Question 6

Phenytoin and Macrolide Antibiotics

Answer 6

elevated concentrations of phenytoin in the blood