Drug Class: MRA Flashcards
1
Q
What does MRA stand for?
A
Mineralocorticoid receptor agonists
2
Q
Examples of MRAs
A
SPIRONOLACTONE
EPLENERONE
3
Q
What is the mode of action of MRA
A
- Potassium sparring diuretic- no filtration of K+
- Inhibit action of aldosterone and other steroid hormones
- Enhanced diuretic effect
- Vasodilatation
4
Q
Side effects of MRA
A
- Renal impairment
- Hyponatraemia
- Hyperkalaemia
- Gynaecomastia (Spiro> Eplenerone)
5
Q
Drug-drug interactions of MRA
A
NSAIDs use with extreme caution
• Marked HYPERKAELAEMIA if AKI
